Childhoood cancer predisposition : Applications of molecular testing and future implications.
The last decade has witnessed tremendous strides in understanding the genetics of cancer.
Identification of additional genes predisposing to childhood cancer. improved understanding of their role in regulation of cell growth, and insight into the environmental and other factors influencing cancer development will help to increase future knowledge in this field.
A major challenge of the next decade will involve translation of this evolving body of knowledge into clinically useful information.
This will require development of rapid. reliable, and less expensive molecular tests for gene testing.
Legislation ensuring confidentiality of genetic information will be critical to protect the privacy of those being tested and to prevent discrimination based on test results.
Finally, genetic testing for cancer risk should lead to development of programs designed to reduce the morbidity and mortality, from primate and secondary cancers.
These programs may include improved cancer treatment and surveillance, behavioral and dietary interventions, and chemoprophylaxis trials.
Because preventive measures such as these would logically be applied to genetically susceptible children and adolescents, it is important that pediatricians follow the progress in this rapidly advancing field of research.
Mots-clés Pascal : Carcinome, Dépistage, Prédisposition, Expression génique, Classification par stade, Etude familiale, Evaluation, Enfant, Homme, Perspective, Etats Unis, Amérique du Nord, Amérique, Tumeur maligne, Carcinogenèse, Déterminisme génétique, Immunopathologie
Mots-clés Pascal anglais : Carcinoma, Medical screening, Predisposition, Gene expression, Stage classification, Family study, Evaluation, Child, Human, Perspective, United States, North America, America, Malignant tumor, Carcinogenesis, Genetic determinism, Immunopathology
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 98-0246866
Code Inist : 002B04E01. Création : 11/09/1998.