Decline in serum antibodies to methyltetrahydrophthalic anhydride after cessation of exposure. Implications for use as a biomarker.
The association between exposure intensity and serum levels of immunoglobulins E and G against low molecular weight compounds was evaluated.
The decay of levels of specific IgE and IgG antibodies was studied after cessation of exposure in workers exposed to the inhalant allergen methyltetrahydrophthalic anhydride in a plant using epoxy resins.
Sera have been collected in workers for 18-84 (mean value 54) months after cessation of exposure.
Specific IgE and IgG was assessed by RAST and ELISA, respectively.
The mean of individual half-times for IgE (N=10) and IgG (N=8) was 0.9 (range 0.1-1.8) and 0.4 (range 0.2-0.6) years, respectively, after total avoidance of exposure.
Corresponding decreases of IgE and IgG were also observed after reduction, but not total elimination, of exposure.
No correlation was seen between biologic half-times of specific IgE and total IgE, atopy, smoking habits or gender.
The results indicate that the levels of specific antibodies in sensitized individuals reflect long term exposure, and may persist for years after the end of exposure.
Mots-clés Pascal : Epoxyde résine, Anhydride organique, Exposition professionnelle, Médecine travail, Homme, Sérum, Surveillance biologique, Liquide biologique, IgE, IgG, Anticorps, Immunoglobuline, Marqueur biologique, Isobenzofurane-1,3-dione(méthyl tétrahydro)
Mots-clés Pascal anglais : Epoxy resin, Organic anhydride, Occupational exposure, Occupational medicine, Human, Serum, Biological monitoring, Biological fluid, IgE, IgG, Antibody, Immunoglobulins, Biological marker
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 98-0246274
Code Inist : 002B03L06. Création : 11/09/1998.