To describe the age-related changes in cardiovascular disease risk factors in young, hypercholesterolemic (HC) children.
Hypercholesterolemic (n=227) and nonhypercholesterolemic (NHC) (n=80) children between the ages of 4 and 10 years were identified.
Height, weight, skin-fold and blood pressure measurements, and total cholesterol levels were measured.
The HC group also had insulin levels evaluated.
The groups were compared by analysis of variance.
Simple Spearman correlations evaluated the associations between factors within each group.
The HC and NHC groups had similar mean ages, heights, and weights, both contained 51% girls, and all were white subjects.
Percent weight-for-height median, and biceps, triceps, suprailiac and subscapular skin-fold measurements were all larger for the HC group.
A significant age interaction demonstrated that the HC group's larger suprailiac and sum of skin-fold measures were expressed in the 8.0-to 9.9-year-old children, but not the 4.0-to 5.9-year-olds.
For both groups, systolic blood pressure was associated with the measures of adiposity.
For the HC group, insulin levels were also associated with adiposity.
These results suggest that : (1) children with HC have greater body fat, (2) the expression of the hypercholesterolemia precedes the expression of increased body fat. (...)
Mots-clés Pascal : Hypercholestérolémie, Etude cohorte, Facteur risque, Cardiopathie, Enfant, Homme, Critère âge, Dépistage, Evaluation, Etats Unis, Amérique du Nord, Amérique, Lipide, Métabolisme pathologie, Dyslipémie, Hyperlipoprotéinémie, Appareil circulatoire pathologie, Education santé
Mots-clés Pascal anglais : Hypercholesterolemia, Cohort study, Risk factor, Heart disease, Child, Human, Age criterion, Medical screening, Evaluation, United States, North America, America, Lipids, Metabolic diseases, Dyslipemia, Hyperlipoproteinemia, Cardiovascular disease, Health education
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 98-0245505
Code Inist : 002B22A. Création : 11/09/1998.