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  1. Serotype distribution of invasive group B streptococcal isolates in maryland : Implications for vaccine formulation.

    Article - En anglais

    Invasive group B streptococcal (GBS) infection is a major health problem among infants and adults.

    The formulation of GBS vaccines depends on knowledge of the GBS serotype distribution.

    Serotype V GBS infection appears to have recently emerged, suggesting that the serotype distribution changes over time.

    GBS isolates from 210 pediatric patients, 23 pregnant women, and 314 nonpregnant adults with invasive infection in Maryland were studied.

    The predominant serotypes from infants with early-onset disease were as follows :

    • serotype III, 38% of isolates ;

    • serotype Ia, 36% ;

    • serotype V, 13% ;

    • and serotype II, 11%. Although the majority (60%) of isolates among infants with late-onset infection were serotype III, serotype la (23%) was also common.

    The predominant serotype among isolates from nonpregnant adult patients was serotype V, accounting for 29% of the isolates.

    The serotype distribution differs between pediatric patients and adults and is changing over time.

    The inclusion of a relatively small number of serotypes in a GBS vaccine could provide protection against the vast majority of isolates.

    Mots-clés Pascal : Streptococcus B, Streptococcaceae, Micrococcales, Bactérie, Isolat clinique, Homme, Maryland, Etats Unis, Amérique du Nord, Amérique, Sérotype, Epidémiologie, Vaccin

    Mots-clés Pascal anglais : Streptococcus B, Streptococcaceae, Micrococcales, Bacteria, Clinical isolate, Human, Maryland, United States, North America, America, Serotype, Epidemiology, Vaccine

    Logo du centre Notice produite par :
    Inist-CNRS - Institut de l'Information Scientifique et Technique

    Cote : 98-0243976

    Code Inist : 002A05B11. Création : 11/09/1998.