logo BDSP

Base documentaire


  1. Durable power of attorney and informed consent with Alzheimer's disease patients : A Clinical study.

    Article - En anglais

    Objective 

    Experience with a new surrogate consent system for patients with Alzheimer's disease is reviewed.

    It was hypothesized that as patients'cognitive status deteriorated, surrogate consent through a durable power of attorney would become necessary to facilitate continued involvement in clinical research.

    Method 

    The authors retrospectively reviewed the charts of in patients with Alzheimer's disease who participated in research between January 1989 and December 1994 at the Geriatric Psychiatry Unit of the National Institute of Mental Health.

    Seventy-nine patients were included

    The main outcome measures were the Clinical Dementia Rating, Global Deterioration Scale for primary degenerative dementia, and Mini-Mental State.

    Results 

    Most patients were in the mild-to-moderate stage of the illness when they chose to participate in research and assign a durable power of attorney (96% scored 2 or less on the Clinical Dementia Rating, and 92% scored or less on the Global Deterioration Scale).

    On average, the subjects participated in 3.8 (SD=2.6) studies.

    For 35 patients with multiple admissions over this period (average=3.1 years), scores on the Clinical Dementia Rating and Global Deterioration Scale declined by 1.0 and 1.5 points, respectively.

    Conclusions 

    The durable power of attorney allows research participation for subjects with Alzheimer's disease at all stages. (...)

    Mots-clés Pascal : Démence Alzheimer, Recherche scientifique, Expérimentation, Participation, Consentement éclairé, Aptitude, Détérioration intellectuelle, Ethique, Etats Unis, Amérique du Nord, Amérique, Homme, Système nerveux pathologie, Système nerveux central pathologie, Encéphale pathologie, Maladie dégénérative

    Mots-clés Pascal anglais : Alzheimer disease, Scientific research, Experimentation, Participation, Informed consent, Ability, Intellectual deterioration, Ethics, United States, North America, America, Human, Nervous system diseases, Central nervous system disease, Cerebral disorder, Degenerative disease

    Logo du centre Notice produite par :
    Inist-CNRS - Institut de l'Information Scientifique et Technique

    Cote : 98-0243655

    Code Inist : 002B30A09. Création : 11/09/1998.