Evaluating toxic impact assessment methods : What works best ?
An analysis was conducted that tested the usefulness of four methods-toxicity-based scoring, sustainable process index, concentration/toxicity equivalency, and human toxicity potential-for assessing human health impacts of chemical emissions.
Each assessment method uses a different model with varying levels of complexity and sophistication to calculate a toxic equivalency potential.
This indicator is a ratio that expresses human health risks associated with release of a toxic chemical relative to those of an equivalent, equally toxic release of a reference chemical.
Predicted impacts of the compared toxicants depend on whether and how exposure is considered by each evaluation method.
Relative toxicity scores produced by these methods vary by 3 orders of magnitude when the same compounds are analyzed ; thus, method selection is critical.
The human toxicity potential method is preferred for comparing toxic emissions.
Of the four methods investigated, it incorporates the most comprehensive approach to exposure assessment.
Pollutants are ranked on the basis of health risks, assessed by using an explicit characterization of total human exposure to a toxicant.
Mots-clés Pascal : Composé chimique, Toxicité, Méthode étude, Etude comparative, Validation test, Homme, Evaluation, Prédiction, Polluant, Facteur équivalence toxique
Mots-clés Pascal anglais : Chemical compound, Toxicity, Investigation method, Comparative study, Test validation, Human, Evaluation, Prediction, Pollutant, Toxic equivalency factor
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 98-0242884
Code Inist : 002B03A. Création : 11/09/1998.