The pathogenic 16/6 idiotype in patients with silica associated systemic lupus erythematosus (SLE) and uranium miners with increased risk for development of SLE.
To investigate the prevalence of the 16/6 idiotype (16/6 Id), a major cross reactive idiotype of anti-DNA antibodies involved in the pathogenesis of experimental lupus, in subjects with an exogenous risk for the development of systemic lupus erythematosus (SLE).
The titer of 16/6 Id was determined by ELISA in sera of uranium miners exposed to heavy quartz dust : 15 developed definite and 12 probable SLE, 34 had clinical symptoms, and 27 had only serological signs (medium to high titer anti-dsDNA antibodies) of possible connective tissue disease (CTD) development.
The prevalence of 16/6 Id was higher in all groups compared to healthy blood donors.
It was 18.5% in miners with SLE (definite and probable) and 22.2-26.5% in miners with clinical and/or serological signs for developing CTD.
All 16/6 Id positive miners were positive for anti-dsDNA antibodies and other autoantibodies associated with CTD.
The prevalence of 16/6 Id in anti-dsDNA positive miners correlated slightly with CTD/SLE symptoms : 55.6% in patients with SLE. 47.4% in miners with possible CTD/SLE, and 22.2% in miners without CTD symptoms.
Further, at short term followup, disease progressed in 2 miners of the 16/6 Id positive, but not in 16/6 Id negative miners. (...)
Mots-clés Pascal : Lupus érythémateux, Disséminé, Pathogénie, Anticorps, Autoanticorps, DNA, Technique ELISA, Idiotype, Exploration, Epidémiologie, Prévalence, Facteur risque, Silice, Uranium, Association, Poste travail, Homme, Exploitation minière, Peau pathologie, Tissu conjonctif pathologie, Maladie système, Maladie autoimmune, Immunopathologie
Mots-clés Pascal anglais : Lupus erythematosus, Disseminated, Pathogenesis, Antibody, Autoantibody, DNA, ELISA assay, Idiotype, Exploration, Epidemiology, Prevalence, Risk factor, Silica, Uranium, Association, Workplace layout, Human, Mining, Skin disease, Connective tissue disease, Systemic disease, Autoimmune disease, Immunopathology
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 98-0236445
Code Inist : 002B07. Création : 11/09/1998.