To determine onset subtypes and HLA associations of juvenile rheumatoid arthritis (JRA) in a First Nations (aboriginal) population ; to determine whether population frequencies of HLA antigens may explain the distribution of subtypes of JRA in this population.
All patients were children from Manitoba and Northwestem Ontario seen in a single pediatric rheumatology clinic between 1975 and 1996.
Patients were identified from a clinic registry.
Controls were adults of Algonkian Cree and Ojibway heritage.
Class I and II major histocompatibility (HLA) typing was performed for First Nations patients and controls.
There were a total of 74 First Nations patients with JRA.
The relative frequency of rheumatoid factor (RF) positive polyarticular JRA was higher and that of pauciarticular JRA was lower in First Nations compared with Caucasian patients (42 versus 3% and 22 versus 58%, respectively ; p=0.00000).
HLA-DRB1*04 (63%), 08 (43%), and 1402 (25%) were the most common DRB I antigens among controls.
The main subtypes of DRB1*04 were 0404 (33% of controls) and 0407 (23%). HLA typing was performed for 39 First Nations patients ; 27 were Cree or Ojibway, 4 were from other tribes, and 8 were part First Nations.
Among Cree and Ojibway, 59% of controls and 63% of patients with RF positive polyarticular JRA (n=16) had HLA-DRB1 antigens bearing the rheumatoid arthritis (RA) shared epitope (OR 1.16,95% CI : 0.38,3.48). (...)
Mots-clés Pascal : Arthrite chronique juvénile, Enfant, Homme, Pathogénie, Epidémiologie, Ethnie, Aborigène, Déterminisme génétique, Système HLA, Antigène histocompatibilité classe I, Antigène histocompatibilité classe II, Canada, Amérique du Nord, Amérique, Chronique, Système ostéoarticulaire pathologie, Rhumatisme inflammatoire, Génétique
Mots-clés Pascal anglais : Juvenile rheumatoid arthritis, Child, Human, Pathogenesis, Epidemiology, Ethnic group, Aboriginal, Genetic determinism, HLA-System, Class I histocompatibility antigen, Class II histocompatibility antigen, Canada, North America, America, Chronic, Diseases of the osteoarticular system, Inflammatory joint disease, Genetics
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 98-0236388
Code Inist : 002B15D. Création : 11/09/1998.