We investigated colour vision impairment in 45 male workers occupationally exposed to toluene (mean value of toluene concentration in ambient air=119.96 ppm) and in 53 controls.
Colour vision was evaluated by Lanthony-D-15 desaturated test and expressed as Age and Alcohol Intake Adjusted Colour Confusion Score (AACDS) or types of dyschromatopsia.
Exposure was evaluated by measurement of toluene concentration in ambient air and blood, and hippuric acid and orthocresol determined in urine after the workshift.
A statistically significant higher AACDS value was established in the exposed subjects compared to the controls (p<0.0001).
There was no significant difference between AACDS values on Wednesday morning compared to Monday morning.
In the exposed group AACDS significantly correlated with the concentration of toluene in ambient air, concentration of toluene in blood and the concentration of hippuric acid in urine after the workshift (all p<0.0001).
Dyschromatopsias were detected in both groups, although no significant difference between groups was established.
In the exposed group, concentration of toluene in ambient air, alcohol intake and age explained 35.1%, concentration of toluene in blood, age and alcohol intake explained 19.9%, and concentration of hippuric acid in urine and age explained 19.2% of the variation in type Ill dyschromatopsia.
Concentration of toluene in ambient air and age explained 28. (...)
Mots-clés Pascal : Toluène, Solvant organique, Toxicité, Exposition professionnelle, Médecine travail, Trouble vision, Vision couleur, Réversibilité, Homme, Oeil pathologie, Système nerveux pathologie
Mots-clés Pascal anglais : Toluene, Organic solvent, Toxicity, Occupational exposure, Occupational medicine, Vision disorder, Color vision, Reversibility, Human, Eye disease, Nervous system diseases
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 98-0235784
Code Inist : 002B03L04. Création : 11/09/1998.