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  1. Sibship size, birth order, and atopy in 11,371 Italian young men.

    Article - En anglais


    Having a low number of siblings and a low birth order has been reported to be a relevant risk factor for development of atopic diseases and skin sensitization to common inhalants.

    Although the inverse association of atopy with sibship size has been confirmed repeatedly, the association with birth order has provided conflicting results.

    This possibly is due to the relatively small size of the population sample examined.


    The objective of this study was to investigate the relation between sibship size, birth order, and atopy in a very large population sample, highly homogeneous for age and sex.


    This was a retrospective survey of 11,371 Italian young men, 18 to 24 years old, all candidates for enrollment in the Italian Air Force.

    Demographic data had been collected by a standard questionnaire.

    Specific IgE for locally relevant airborne allergens had been tested by a multi-RAST assay (CAP-Phadiatop).


    The prevalence of atopy (defined as a high level of specific IgE against inhalants [cut-point>1.2 log RU]) was inversely related to the total number of siblings (25% in those with no siblings and 9% in those with five or more siblings), with a mean of a 3% decrease in prevalence for each added sibling.

    This relation persisted after adjustment for relevant variables such as father's education and rural and southern residence. (...)

    Mots-clés Pascal : Rang naissance, Fratrie, Dimension famille, Facteur risque, Adulte jeune, Homme, Mâle, Epidémiologie, Italie, Europe, Atopie, IgE, Immunopathologie, Allergie, Infection

    Mots-clés Pascal anglais : Birth order, Sibling, Family size, Risk factor, Young adult, Human, Male, Epidemiology, Italy, Europe, Atopy, IgE, Immunopathology, Allergy, Infection

    Logo du centre Notice produite par :
    Inist-CNRS - Institut de l'Information Scientifique et Technique

    Cote : 98-0233855

    Code Inist : 002B06C02. Création : 11/09/1998.