Carcinoma of the pancreas is the fifth leading cancer in the U. S. and has the poorest survival rate of the major malignancies.
Recent studies have reported an increased risk of carcinoma of the pancreas in malignant melanomaprone kindreds and have suggested a link between malignant melanoma and pancreas carcinoma and mutations in the p16INK4 gene.
This study evaluates the risk of carcinoma of the pancreas in a population-based cohort of patients with malignant melanoma.
The malignant melanoma patients were identified from the Surveillance, Epidemiology, and End Results (SEER) program of the National Cancer Institute.
The cohort was followed within the SEER system to ascertain the occurrence of subsequent microscopically confirmed primary carcinoma of the pancreas from January 1973 through December 1993.
The time of follow-up was expressed as person-years of observation.
Standardized incidence ratios (SIR) and 95% confidence intervals (95% Cl) were calculated.
There were 43,781 malignant melanoma patients providing 263,528 person-years of follow-up.
A nearly 2-fold increased risk of subsequent carcinoma of the pancreas in patients diagnosed with malignant melanoma before age 50 years was observed (SIR=1.76 ; 95% Cl=0.80-3.34) and the greatest estimated risk occurred in young white females (SIR=2.27 ; 95% CI=0.73-5.30). (...)
Mots-clés Pascal : Mélanome, Peau, Facteur risque, Carcinome, Pancréas, Second cancer, Epidémiologie, Etats Unis, Amérique du Nord, Amérique, Homme, Tumeur maligne, Peau pathologie, Pancréas pathologie, Appareil digestif pathologie
Mots-clés Pascal anglais : Melanoma, Skin, Risk factor, Carcinoma, Pancreas, Second cancer, Epidemiology, United States, North America, America, Human, Malignant tumor, Skin disease, Pancreatic disease, Digestive diseases
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 98-0233820
Code Inist : 002B13C01. Création : 11/09/1998.