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  1. Incidence, etiologic aspects and clinicopathologic features in intrahepatic cholangiocellular carcinoma : A study of 51 cases from a low-endemicity area.

    Article - En anglais

    A total of 51 cases (19 males and 32 females) of intrahepatic cholangiocellular carcinoma (CCC) from a low-endemicity area of primary liver cancer was analyzed during the periods from 1958 to 1979 and from 1984 to 1991.

    The mean annual age-adjusted incidence rate was 0.44 for males and 0.56 for females per 100000 inhabitants.

    CCC was diagnosed before death in only 31%. There was a female predominance in patients over 70 years of age (p<0.05).

    At presentation, malaise (85%), weight loss (73%), abdominal pain (50%) and hepatomegaly (80%) were common.

    The median survival time from diagnosis was 2 months.

    The mean age at the time of death was 72 years (range 41-92).

    At autopsy, cholelithiasis was found in 61% (81% in patients older than 70 years) and cirrhosis in 30% of patients.

    Cholelithiasis was more common in CCC (p<0.01) than in hepatocellular carcinoma cases with the same mean age.

    Not one case of inflammatory bowel disease was found.

    The gross appearance of the tumor was predominantly massive (49%) or multinodular (35%). The most common histological features were tubular pattern of growth (82%) and abundant fibrous stroma.

    Metastases were particularly associated with the lymph nodes (41%), skeleton (26%) and lungs (16%).

    Mots-clés Pascal : Cholangiome malin, Carcinome, Intrahépatique, Incidence, Epidémiologie, Suède, Europe, Etiologie, Histopathologie, Structure macroscopique, Microscopie, Métastase, Pronostic, Type histologique, Homme, Appareil digestif pathologie, Foie pathologie, Voie biliaire pathologie, Tumeur maligne, Anatomopathologie

    Mots-clés Pascal anglais : Malignant cholangioma, Carcinoma, Intrahepatic, Incidence, Epidemiology, Sweden, Europe, Etiology, Histopathology, Macroscopic structure, Microscopy, Metastasis, Prognosis, Histological type, Human, Digestive diseases, Hepatic disease, Biliary tract disease, Malignant tumor, Pathology

    Logo du centre Notice produite par :
    Inist-CNRS - Institut de l'Information Scientifique et Technique

    Cote : 98-0233092

    Code Inist : 002B13C01. Création : 11/09/1998.