The Swedish National Care Programme for Anal Carcinoma (SNCPAC) was instituted in order to create a uniform handling policy for anal cancer and thus to accrue a population-based material allowing unbiased analyses.
This study evaluates the degree of implementation of the SNCPAC guidelines, and presents overall treatment results in a total of 356 patients with epidermoid cancer of the anus and the perianal region diagnosed in Sweden between 1985 and 1989.
Primary treatment according to the guidelines was irradiation up to 40 Gy.
Bleomycin was administered intramuscularly before the first 18 fractions.
After a 3-week pause, radiotherapy was to be continued up to a dose of 60-64 Gy, if at least an almost complete response was achieved.
Otherwise, the patient was recommended surgery within a week.
The guidelines were applied in 90%, of cases where such treatment was possible.
The 5-year tumour-specific survival rate was 72%. The survival rate was more favourable in perianal tumours (90%) than in anal canal tumours (68%, p<0.01).
The 5-year probability of having a preserved anus was 64% (anal canal/perianal 58%/91%, p<0.001).
Bleomycin did not appear to have any effect on treatment results.
The care programme has had a rapid and almost complete nation-wide penetration, and h as created the desired uniformity allowing proper analyses.
The treatment results also appear comparable with specialised referral centres.
Mots-clés Pascal : Carcinome épidermoïde, Anus, Radiothérapie, Bléomycine, Antibiotique, Anticancéreux, Chirurgie, Exérèse, Traitement, Recommandation, Suède, Europe, Pronostic, Chimiothérapie, Programme sanitaire, Homme, Tumeur maligne, Anorectale pathologie, Intestin pathologie, Appareil digestif pathologie
Mots-clés Pascal anglais : Squamous cell carcinoma, Anus, Radiotherapy, Bleomycin, Antibiotic, Antineoplastic agent, Surgery, Exeresis, Treatment, Recommendation, Sweden, Europe, Prognosis, Chemotherapy, Sanitary program, Human, Malignant tumor, Anorectal disease, Intestinal disease, Digestive diseases
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 98-0233085
Code Inist : 002B13B01. Création : 11/09/1998.