To obtain quantitative information on the risk of invasive cancers following a diagnosis of basal cell carcinoma (BCC) of the skin, patients with incident BCC cases listed in the cancer registries of the Swiss cantons of Vaud and Neuchâtel between 1974 and 1994 were actively followed up through December 31,1994, for the occurrence of subsequent invasive neoplasms.
Among 11,878 persons with incident BCC who were followed for a total of 76,510 person-years at risk, 1,543 metachronous cancers were observed versus 1,397.9 expected, corresponding to a standardized incidence ratio (SIR) of 1.1 (95% confidence interval (Cl) 1.0-1.2).
However, after exclusion of skin cancers (mostly squamous cell carcinoma and melanoma), 975 second primary cancers were observed versus 1,059 expected (SIR=0.9,95% Cl 0.8-1.0).
Significant excesses were registered for cancer of the lip (SIR=2.2), for squamous cell skin cancer (SIR=4.5) and melanoma of the skin (SIR=2.5), and for non-Hodgkin's lymphoma (SIR=1.9).
The SlRs were also above unity, though not significantly, for cancers of the salivary glands (SIR=2.8) and the small intestine (SIR=2.1) and for soft-tissue sarcomas (SIR=1.7).
The SIR for lung cancer was 0.9. The SlRs for salivary gland and skin cancer were appreciably greater below age 70 years.
For most sites, particularly for squamous cell cancer and melanoma of the skin, the SlRs remained elevated 5 or more years after BCC diagnosis. (...)
Mots-clés Pascal : Carcinome basocellulaire, Second cancer, Registre, Epidémiologie, Incidence, Homme, Suisse, Europe, Peau pathologie, Tumeur maligne
Mots-clés Pascal anglais : Basal cell carcinoma, Second cancer, Register, Epidemiology, Incidence, Human, Switzerland, Europe, Skin disease, Malignant tumor
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 98-0232749
Code Inist : 002B08A. Création : 11/09/1998.