Objectives-To investigate mortality from lung cancer in nickel/chromium platers.
Methods-The mortality experience of a cohort of 1762 chrome workers (812 men, 950 women) from a large electroplating and light engineering plant in the Midlands, United Kingdom, was investigated for the period 1946-95.
All subjects were first employed in chrome work at the plant during the period 1946-75, and had at least six months employment in jobs associated with exposure to chromic acid mist (hexavalent chromium).
Detailed job histories were abstracted from original company personnel records and individual cumulative durations of employment in three types of chrome work were derived as time dependent variables (chrome bath work, other chrome work, any chrome work).
Two analytical approaches were used-indirect standardisation and Poisson regression.
Result-Based on mortalities for the general population of England and Wales, male workers with some period of chrome bath work had higher lung cancer mortalities (observed deaths 40, expected deaths 25.41, standardised mortality ratio (SMR) 157,95% confidence interval (95% CI) 113 to 214, p<0.01) than did other male chrome workers (observed 9, expected 13.70, SMR 66,95% CI 30 to 125).
Similar findings were shown for female workers (chrome bath workers : observed 15, expected 8.57, SMR 175,95% CI 98 to 289, p=0.06 ; other chrome workers : observed 1, expected 4.37, SMR 23,95% CI 1 to 127). (...)
Mots-clés Pascal : Industrie métallurgique, Nickel, Chrome, Placage, Mortalité, Tumeur maligne, Bronchopulmonaire, Dépôt électrolytique, Royaume Uni, Europe, Exposition professionnelle, Médecine travail, Homme, Epidémiologie, Toxicité, Appareil respiratoire pathologie, Poumon pathologie, Bronche pathologie, Carcinogène, Etude cohorte, Etude longitudinale
Mots-clés Pascal anglais : Metallurgical industry, Nickel, Chromium, Plating, Mortality, Malignant tumor, Bronchopulmonary, Electrodeposition, United Kingdom, Europe, Occupational exposure, Occupational medicine, Human, Epidemiology, Toxicity, Respiratory disease, Lung disease, Bronchus disease, Carcinogen, Cohort study, Follow up study
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 98-0229723
Code Inist : 002B11A. Création : 11/09/1998.