Systemic lupus erythematosus in Denmark : Clinical and epidemiological characterization of a county-based cohort.
A population based cohort of patients with systemic lupus erythematosus (SLE) was recruited from a for epidemiological purposes representative Danish region.
Patients were ascertained from 4 different sources with a high degree of completeness as estimated by using capture-recapture analysis.
The diagnosis was verified by means of case records, patient interviews, and clinical examinations.
Patients were classified according to the 1982 revised ACR criteria as Definite SLE (D-SLE) fulfilling =4 criteria and Incomplete SLE (I-SLE) with<4 criteria.
As of January 1,1995, the point prevalences of D-SLE and I-SLE were 21.7 and 5.2 per 100 000 respectively.
The cohort comprised 98% white Europeans.
The annual incidence of D-SLE increased from 1.0/100000 to 3.6/100000 during the study period 1980-94.
D-SLE patients had clinical profiles comparable to other Western European study populations.
The I-SLE subclass had milder disease manifested by lower criterial load and absence of cerebral and kidney involvement.
Tissue and organ damage expressed as SLICC-score increased in the order of live I-SLE, live D-SLE, and deceased patients.
Mots-clés Pascal : Lupus érythémateux, Disséminé, Pathogénie, Epidémiologie, Incidence, Prévalence, Symptomatologie, Diagnostic, Classification, Anticorps, Autoanticorps, DNA bicaténaire, Homme, Peau pathologie, Tissu conjonctif pathologie, Maladie système, Maladie autoimmune, Immunopathologie
Mots-clés Pascal anglais : Lupus erythematosus, Disseminated, Pathogenesis, Epidemiology, Incidence, Prevalence, Symptomatology, Diagnosis, Classification, Antibody, Autoantibody, Double stranded DNA, Human, Skin disease, Connective tissue disease, Systemic disease, Autoimmune disease, Immunopathology
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 98-0229686
Code Inist : 002B07. Création : 11/09/1998.