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  1. Systemic lupus erythematosus in Denmark : Clinical and epidemiological characterization of a county-based cohort.

    Article - En anglais

    A population based cohort of patients with systemic lupus erythematosus (SLE) was recruited from a for epidemiological purposes representative Danish region.

    Patients were ascertained from 4 different sources with a high degree of completeness as estimated by using capture-recapture analysis.

    The diagnosis was verified by means of case records, patient interviews, and clinical examinations.

    Patients were classified according to the 1982 revised ACR criteria as Definite SLE (D-SLE) fulfilling =4 criteria and Incomplete SLE (I-SLE) with<4 criteria.

    As of January 1,1995, the point prevalences of D-SLE and I-SLE were 21.7 and 5.2 per 100 000 respectively.

    The cohort comprised 98% white Europeans.

    The annual incidence of D-SLE increased from 1.0/100000 to 3.6/100000 during the study period 1980-94.

    D-SLE patients had clinical profiles comparable to other Western European study populations.

    The I-SLE subclass had milder disease manifested by lower criterial load and absence of cerebral and kidney involvement.

    Tissue and organ damage expressed as SLICC-score increased in the order of live I-SLE, live D-SLE, and deceased patients.

    Mots-clés Pascal : Lupus érythémateux, Disséminé, Pathogénie, Epidémiologie, Incidence, Prévalence, Symptomatologie, Diagnostic, Classification, Anticorps, Autoanticorps, DNA bicaténaire, Homme, Peau pathologie, Tissu conjonctif pathologie, Maladie système, Maladie autoimmune, Immunopathologie

    Mots-clés Pascal anglais : Lupus erythematosus, Disseminated, Pathogenesis, Epidemiology, Incidence, Prevalence, Symptomatology, Diagnosis, Classification, Antibody, Autoantibody, Double stranded DNA, Human, Skin disease, Connective tissue disease, Systemic disease, Autoimmune disease, Immunopathology

    Logo du centre Notice produite par :
    Inist-CNRS - Institut de l'Information Scientifique et Technique

    Cote : 98-0229686

    Code Inist : 002B07. Création : 11/09/1998.