Exposure of workers to 2,3,7,8-substituted polychlorinated dibenzo-p-dioxin (PCDD) and dibenzofuran (PCDF) compounds in sawmills previously using chlorophenol-containing antistain agents.
The use of chlorophenol-containing antistain agents (e.g., Ky5, a wood preservative) ceased in Finland at the end of the 1980s, after 5 decades of use.
Exposure of workers to the impurities in these agents (i.e., polychlorinated dibenzo-dioxins [PCDDs] and dibenzofurans [PCDFs]) was assessed at three sawmills at which personnel used a sodium chlorophenate product as an antistain agent.
Given that compounds accumulate in body fat and their half-lives in humans are long, we could determine 2,3,7,8-substituted PCDDs and PCDFs 5-9 y after the last exposure occurred.
We used high-resolution gas chromatography/high-resolution mass spectrometry to determine PCDDs/PCDFs in plasma from 39 Ky5-exposed workers and 18 nonexposed workers.
The average total plasma concentration of PCDD/PCDF of the Ky5-exposed workers at the three sawmills were 1 018,945, and 1 165 pg/g fat, and corresponding concentrations in the nonexposed workers were 743,1 124, and 844 pg/g fat, respectively.
We found no significant differences in total levels between Ky5-exposed workers and nonexposed workers.
However, concentrations of the 1,2,3,4,6,7,8-HpCDF isomer were significantly higher (p<. 01) among the Ky5-exposed workers at all three sawmills (averages of 224,99, and 148 pg/g fat) than among their respective nonexposed workers (averages of 43,48, and 44 pg/g fat).
These results indicate that workers had handled Ky5. (...)
Mots-clés Pascal : Pesticide, Chlorophénol, Fongicide, Conservateur, Bois, Scierie, Industrie bois, Exposition professionnelle, Médecine travail, Homme, Finlande, Europe, Impureté, Dibenzofurane(polychloro), Dibenzo-p-dioxine(polychloro), Persistance, Sol, Agent protection, Dibenzo-p-dioxine(2,3,7,8-tétrachloro)
Mots-clés Pascal anglais : Pesticides, Chlorophenol, Fungicide, Preservative, Wood, Saw mill, Wood industry, Occupational exposure, Occupational medicine, Human, Finland, Europe, Impurity, Persistence, Soils, Preservation agent
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 98-0229595
Code Inist : 002B03L06. Création : 11/09/1998.