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  1. Epidemiological and clinical aspects of hepatitis G virus infection in blood donors and immunocompromised recipients of HGV-contaminated blood.

    Article - En anglais

    Background and objectives 

    The infectiousness and clinical relevance of the newly discovered blood-borne Flaviviridae-like agent, termed hepatitis G virus (HGV), are not well understood.

    Materials and methods 

    Twenty-three transfusion recipients of two HGV-affected long-term blood donors were studied for HGV genome and antibodies to the putative envelope 2 glycoprotein (anti-E2) of HGV.

    Nine recipients had nonhematological disorders and 14 suffered from severe hematological diseases and 7 of them received allogeneic bone marrow or blood stem cell transplantation.

    The molecular epidemiology of the observed HGV infection was studied by direct sequencing of parts of the 5'-noncoding region, NS3, and NS5 region of HGV in the 2 long-term donors and in their 6 recipients who became HGV RNA positive.

    Additionally, 549 individuals - homologous (n=254) and autologous blood donors (n=202), and medical staff (n=89) - were investigated for the presence of HGV RNA.

    Results 

    HGV RNA in serum was found in 15 of the 23 (65%) transfusion recipients with known exposure of HGV-contaminated blood.

    Seven of the remaining 8 recipients showed only an anti-E2 response, indicating previous HGV infection with spontaneous clearance of the virus.

    In one recipient neither HGV RNA nor anti-E2 could be detected.

    Molecular evidence for HGV transmission by the 2 donors was found in 3 of the 6 recipients studied. (...)

    Mots-clés Pascal : Donneur sang, Epidémiologie moléculaire, Allemagne, Europe, Anémie aplasique, Hémopathie maligne, Transfusion, Sang, Contamination, Traitement, Complication, Homme, Hémopathie, Hépatite virale G

    Mots-clés Pascal anglais : Blood donor, Molecular epidemiology, Germany, Europe, Aplastic anemia, Malignant hemopathy, Transfusion, Blood, Contamination, Treatment, Complication, Human, Hemopathy, Viral hepatitis G

    Logo du centre Notice produite par :
    Inist-CNRS - Institut de l'Information Scientifique et Technique

    Cote : 98-0229275

    Code Inist : 002B27D01. Création : 11/09/1998.