Epidemiological and clinical aspects of hepatitis G virus infection in blood donors and immunocompromised recipients of HGV-contaminated blood.
Background and objectives
The infectiousness and clinical relevance of the newly discovered blood-borne Flaviviridae-like agent, termed hepatitis G virus (HGV), are not well understood.
Materials and methods
Twenty-three transfusion recipients of two HGV-affected long-term blood donors were studied for HGV genome and antibodies to the putative envelope 2 glycoprotein (anti-E2) of HGV.
Nine recipients had nonhematological disorders and 14 suffered from severe hematological diseases and 7 of them received allogeneic bone marrow or blood stem cell transplantation.
The molecular epidemiology of the observed HGV infection was studied by direct sequencing of parts of the 5'-noncoding region, NS3, and NS5 region of HGV in the 2 long-term donors and in their 6 recipients who became HGV RNA positive.
Additionally, 549 individuals - homologous (n=254) and autologous blood donors (n=202), and medical staff (n=89) - were investigated for the presence of HGV RNA.
HGV RNA in serum was found in 15 of the 23 (65%) transfusion recipients with known exposure of HGV-contaminated blood.
Seven of the remaining 8 recipients showed only an anti-E2 response, indicating previous HGV infection with spontaneous clearance of the virus.
In one recipient neither HGV RNA nor anti-E2 could be detected.
Molecular evidence for HGV transmission by the 2 donors was found in 3 of the 6 recipients studied. (...)
Mots-clés Pascal : Donneur sang, Epidémiologie moléculaire, Allemagne, Europe, Anémie aplasique, Hémopathie maligne, Transfusion, Sang, Contamination, Traitement, Complication, Homme, Hémopathie, Hépatite virale G
Mots-clés Pascal anglais : Blood donor, Molecular epidemiology, Germany, Europe, Aplastic anemia, Malignant hemopathy, Transfusion, Blood, Contamination, Treatment, Complication, Human, Hemopathy, Viral hepatitis G
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 98-0229275
Code Inist : 002B27D01. Création : 11/09/1998.