In order to evaluate the association between seropositivity for herpes simplex virus (type 1 and type 2) and cervical intraepithelial neoplacia (CIN), we analysed data from a population-based case-control study of CIN grade II-III which included Norwegian women aged 20 to 44 years, 94 cases and 228 controls.
Our objectives were to determine if HSV-I and/or HSV-2 seropositivity were independent risk factors for CIN, taking human papillomavirus exposure into account, and to elucidate the combined effect of HPV positivity and seropositivity for HSV.
In logistic regression analyses, the association between HSV-2 or HSV-I seropositivity and CIN II-III was not explained by HPV (adjusted OR 3.0 ; 95% CI 1.3-7.2 and adjusted OR 3.3 ; 95% CI 1.3-8.4, respectively).
In analyses restricted to HPV-16 DNA-positive individuals, seropositivity for HSV-2 increased the risk of CIN (OR 11.1 ; 95% Cl 1.2-105.7), whereas HSV-I seropositivity was not significantly associated with CIN.
In women positive for other HPV types, only HSV-I seropositivity was associated with CIN (OR 8.5 ; 95% CI 1.3-55.8).
In analyses of the HPV-16-seropositive individuals, neither HSV-I nor HSV-2 seropositivity was associated with CIN.
Compared to the reference group of jointly unexposed subjects, the HPV-16 DNA-positive women who were anti-HSV-2 negative had an increased risk of CIN (OR 29 ; 95% CI 12-67), whereas the risk in women who were both HPV-16 DNA-positive and HSV-2 was OR=247 (95% CI 31-1996). (...)
Mots-clés Pascal : Dysplasie, Cancer in situ, Carcinome, Col utérus, Virose, Infection, Papillomavirus humain, Papillomavirus, Papovaviridae, Virus, Herpesvirus hominis 1, Alphaherpesvirinae, Herpesviridae, Herpesvirus hominis 2, Interaction, Carcinogenèse, Facteur risque, Epidémiologie, Etude cas témoin, Norvège, Europe, Homme, Lésion précancéreuse, Appareil génital femelle pathologie, Col utérus pathologie, Tumeur maligne
Mots-clés Pascal anglais : Dysplasia, Carcinoma in situ, Carcinoma, Uterine cervix, Viral disease, Infection, Human papillomavirus, Papillomavirus, Papovaviridae, Virus, Herpesvirus hominis 1, Alphaherpesvirinae, Herpesviridae, Herpesvirus hominis 2, Interaction, Carcinogenesis, Risk factor, Epidemiology, Case control study, Norway, Europe, Human, Premalignant lesion, Female genital diseases, Uterine cervix diseases, Malignant tumor
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 98-0226403
Code Inist : 002B20C02. Création : 11/09/1998.