Effect of mammographic breast density on breast cancer screening performance : a study in Nijmegen, the Netherlands.
Study objective-To study the implications of breast density on mammographic screening performance.
Design-Screening outcomes of women with dense breast patterns were compared with those of women with lucent breast patterns (dense>25% densities, lucent <= 25% densities) ; the women were screened in different periods (before/after improvement of the mammographic technique in 1982).
Setting-Nijmegen, the Netherlands, 1977-1994.
Participants-Between 1977 and 1994,73 525 repeat screenings were performed in 19 152 participants (aged 50-69 years) in the Nijmegen breast cancer screening programme (repeat screenings were defined as mammographic examinations that were preceded by an examination in the previous screening round).
Participants were screened biennially with mammography.
There were 258 screen detected and 145 interval cancers.
Main results-Before 1982 (rounds 2-4) the predictive value ofa positive screening test (PV+) was lower in women with dense breasts than in those with lucent breasts (dense 29% v lucent 52%, p=0.003).
Also, the ratio of screen detected cancers to the total number of screen detected plus interval cancers (as a proxy for sensitivity) was lower in this group (based on a one year interval : dense 63% v lucent 92%, p=0.001 and based on a two year interval : dense 41% v lucent 68%, p=0.002).
Moreover, the survival rate was less favourable for those with dense breasts (p=0.07). (...)
Mots-clés Pascal : Tumeur maligne, Glande mammaire, Mammographie, Densité, Programme sanitaire, Epidémiologie, Evaluation performance, Diagnostic, Dépistage, Homme, Femelle, Etude comparative, Pays Bas, Europe, Glande mammaire pathologie, Radiodiagnostic
Mots-clés Pascal anglais : Malignant tumor, Mammary gland, Mammography, Density, Sanitary program, Epidemiology, Performance evaluation, Diagnosis, Medical screening, Human, Female, Comparative study, Netherlands, Europe, Mammary gland diseases, Radiodiagnosis
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 98-0224182
Code Inist : 002B20E02. Création : 11/09/1998.