Ethical challenges in efficacy trials of vaginal microbicides for HIV prevention : Ethics and studies of HIV.
This paper discusses some of the ethical challenges raised by advanced clinical trials designed to assess the safety and efficacy of vaginal microbicides in protecting women from HIV infection.
The ethical principles that guide clinical research involving human subjects require that all participants in such trials be provided available measures known to reduce the risk of HIV infection.
However, this will reduce the ability of the study to assess the protective effect of the test microbicide.
In addition, providing extensive services to trial participants may be construed as an undue inducement if the study is being conducted among vulnerable groups such as sex workers or women from disadvantaged communities.
Suggestions are provided to resolve this dilemma in the planning and implementation of HIV prevention services for trial participants.
Mots-clés Pascal : Antimicrobien, Antiinfectieux, Antiviral, Virus immunodéficience humaine, Lentivirus, Retroviridae, Virus, Chimiothérapie, SIDA, Virose, Infection, Voie intravaginale, Essai clinique, Efficacité, Ethique, Prévention, Immunopathologie, Immunodéficit
Mots-clés Pascal anglais : Antimicrobial agent, Antiinfectious, Antiviral, Human immunodeficiency virus, Lentivirus, Retroviridae, Virus, Chemotherapy, AIDS, Viral disease, Infection, Intravaginal administration, Clinical trial, Efficiency, Ethics, Prevention, Immunopathology, Immune deficiency
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 98-0224003
Code Inist : 002B30A09. Création : 11/09/1998.