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  1. Fulltext. Trade-offs in prenatal detection of Down syndrome.

    Article - En anglais

    Fulltext.

    Objectives

    This paper presents the results of different screening policies for prenatal detection of Down syndrome that would allow decision makers to make informed choices.

    Methods

    A decision analysis model was built to compare 8 screening policies with regard to a selected set of outcome measures.

    Probabilities used in the analysis were obtained from official administrative data reports in Spain and Catalonia and from data published in the medical literature.

    Sensitivity analyses were carried out to test the robustness of screening policies'results to changes in uptake rates, diagnostic accuracy, and resources consumed.

    Results

    Selected screening policies posed major trades-offs regarding detection rates, false-positive results, fetal loss, and costs of the programs.

    All outcome measures considered were found quite robust to changes in uptake rates.

    Sensitivity and specificity rates of screening tests were shown to be the most influential factors in the outcome measures considered.

    Conclusions

    The disclosed trade-offs emphasize the need to comprehensively inform decision makers about both positive and negative consequences of adopting one screening policy or another.

    Mots-clés Pascal : Trisomie, Aneuploïdie, Aberration chromosomique, Chromosome G21, Dépistage, Prénatal, Analyse décision, Prise décision, Technique, Coût, Economie santé, Maladie congénitale

    Mots-clés Pascal anglais : Trisomy, Aneuploidy, Chromosomal aberration, Chromosome G21, Medical screening, Prenatal, Decision analysis, Decision making, Technique, Costs, Health economy, Congenital disease

    Logo du centre Notice produite par :
    Inist-CNRS - Institut de l'Information Scientifique et Technique

    Cote : 98-0223999

    Code Inist : 002B23B. Création : 11/09/1998.