Despite the high prevalence of gallbladder disease in industrialized countries, little is known about the predictors of the disease, especially in men.
The authors prospectively studied 16,785 alumni of Harvard University, aged 15-24 years, who were followed for up to 61 years.
The health characteristics of these men were ascertained from their college entrance physical examination done in 1916-1950, and updated via mailed questionnaires in 1962 or 1966 (1962/1966).
Alumni subsequently self-reported physician-diagnosed gallbladder disease on further mailed questionnaires in 1972 or 1977.
Between college time and 1962/1966,371 gallbladder disease cases occurred.
An additional 314 cases occurred after 1962/1966.
With respect to college characteristics, after adjustment for potential confounders, the authors found that body mass index (BMI), smoking, physical activity, blood pressure, and consumption of alcohol, coffee, or tea were unrelated to risk.
However, BMI in 1962/1966 was directly related to risk of subsequent gallbladder disease, as was BMI gain since college (p, trend=0.002 and 0.013, respectively).
Compared with men with BMI<22.0, men with BMI =27.0 had a rate ratio of 2.71 (95% confidence interval (Cl) 1.57-4.66) for risk of contracting the disease.
Men who gained =6.0 BMI units since college had a rate ratio of 1.46 (95% Cl 0.86-2.46) compared with men who gained - 0.9 to+0.9 BMI units. (...)
Mots-clés Pascal : Lithiase, Vésicule biliaire, Tabagisme, Obésité, Indice masse corporelle, Exercice physique, Epidémiologie, Facteur risque, Homme, Mâle, Etude cohorte, Etat nutritionnel, Etats Unis, Amérique du Nord, Amérique, Voie biliaire pathologie, Appareil digestif pathologie, Trouble nutrition
Mots-clés Pascal anglais : Lithiasis, Gallbladder, Tobacco smoking, Obesity, Body mass index, Physical exercise, Epidemiology, Risk factor, Human, Male, Cohort study, Nutritional status, United States, North America, America, Biliary tract disease, Digestive diseases, Nutrition disorder
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 98-0223954
Code Inist : 002B13C03. Création : 11/09/1998.