Environmental endocrine modulators and human health : An assessment of the biological evidence.
Recently, a great deal of attention and interest has been directed toward the hypothesis that exposure, particularly in utero exposure, to certain environmental chemicals might be capable of causing a spectrum of adverse effects as a result of endocrine modulation.
In particular, the hypothesis has focused on the idea that certain organochlorine and other compounds acting as weak estrogens have the capability, either alone or in combination, to produce a variety of adverse effects, including breast, testicular and prostate cancer, adverse effects on male reproductive tract, endometriosis, fertility problems, alterations of sexual behavior, learning disability or delay, and adverse effects on immune and thyroid function.
While hormones are potent modulators of biochemical and physiological function, the implication that exposure to environmental hormones (e.g., xenoestrogens) has this capability is uncertain.
While it is reasonable to hypothesize that exposure to estrogen-like compounds, whatever their source, could adversely affect human health, biological plausibility alone is an insufficient basis for concluding that environmental endocrine modulators have adversely affected humans.
Diethylstilbestrol (DES) is a potent, synthetic estrogen administered under a variety of dosing protocols to millions of women in the belief (now known to be mistaken) that it would prevent miscarriage. (...)
Mots-clés Pascal : Hormonomimétique, Endocrinopathie, Thyroïde, Polluant, Animal, Environnement, Toxicité, Homme, Article synthèse, Diéthylstilbestrol, Tumeur maligne, Glande mammaire, Endométriose, Fertilité, Stérilité, Comportement sexuel, Appareil génital femelle pathologie, Appareil génital mâle pathologie, Immunopathologie, Estrogen like, Hormone like, Phytooestrogène
Mots-clés Pascal anglais : Mimetic hormone, Endocrinopathy, Thyroid gland, Pollutant, Animal, Environment, Toxicity, Human, Review, Diethylstilbestrol, Malignant tumor, Mammary gland, Endometriosis, Fertility, Sterility, Sexual behavior, Female genital diseases, Male genital diseases, Immunopathology
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 98-0223944
Code Inist : 002B03M01. Création : 11/09/1998.