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  1. Relationship between the oncogene activation profiles and the tumor suppressor gene inactivation profiles in 19 human neoplasias : A regression analysis study of the intercancer linkage with the world cancer incidence data.

    Article - En anglais

    This study represents an extension of our statistical studies of age-adjusted incidence rates (AAIRs) of 19 neoplasias from 47 population units of the world.

    We have invented 2 data manipulation methods (topological data conversion and sequential regression analysis method) to estimate separately the intensities of each oncogene activation and tumor suppressor gene inactivation of a given tumor (marker tumor) relative to a counterpart tumor (reference tumor) in terms of r seq value.

    This study prepared the r seq table of all permutations of tumor pairs for each of the 2 cancer genes and for each sex first, and then investigated the relation between the r seq profile of oncogene activation and that of tumor suppressor gene inactivation for each tumor.

    A profile containing 16 (male) or 17 (female) r seq data was prepared for each tumor pair, for each cancer gene, and for each sex.

    The extent of similarity between 2 r seq profiles was assessed by the 1st order regression analysis in terms of the correlation coefficient r value.

    Results obtained are given as follows :

    A) The proportions of both the tumor pairs with r seq values of less than - 0.90 in the oncogene activation tables of two sexes and those with r seq values of more than+0.90 in the tumor suppressor gene inactivation tables of the two sexes were all more than 50%. (...)

    Mots-clés Pascal : Gène suppresseur tumeur, Gène onc, Gène onc cellulaire, Analyse régression, Analyse statistique, Etude statistique, Monde, Epidémiologie, Homme, Biologie moléculaire, Inactivation, Activation, Génétique

    Mots-clés Pascal anglais : Tumor suppressor gene, Onc gene, C-Onc gene, Regression analysis, Statistical analysis, Statistical study, World, Epidemiology, Human, Molecular biology, Inactivation, Activation, Genetics

    Logo du centre Notice produite par :
    Inist-CNRS - Institut de l'Information Scientifique et Technique

    Cote : 98-0223745

    Code Inist : 002B30A01A2. Création : 11/09/1998.