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  1. Do spermicides containing nonoxynol-9 prevent sexually transmitted infections : A meta-analysis.

    Article - En anglais

    Background and Objectives 

    There are conflicting opinions on whether to recommend spermicides containing nonoxynol-9 for prevention of sexually transmitted diseases, including human immunodeficiency virus (HIV).

    Goal : To systematically review and summarize the medical literature on the effect of spermicides containing nonoxynol-9 on prevention of gonorrhea, chlamydial infection, and HIV.

    Study Design 


    Potential articles were identified through computerized literature searches.

    Articles were included if the design was clinical trial, cohort, case-control, or cross-sectional ; original outcome data were presented for gonorrhea, chlamydial infection, or HIV ; and spermicides containing nonoxynol-9 were used separately from other barrier methods.

    Study characteristics including design, population, spermicide dose, and delivery method were abstracted.

    Relative risks (RR) and 95% confidence intervals (CI) were determined from information published in the study or from study authors.

    Summary risk estimates were computed for clinical trials.


    Twelve eligible articles were identified, including six clinical trials and six observational studies.

    Eleven articles evaluated gonorrhea ; each found a reduced risk of infection with spermicide use.

    Among six clinical trials, the summary RR was 0.62 (95% CI, 0.49-0.78). (...)

    Mots-clés Pascal : Prévention, Maladie sexuellement transmissible, Spermicide, Nonoxinol, Efficacité, Revue bibliographique, Homme

    Mots-clés Pascal anglais : Prevention, Sexually transmitted disease, Spermicide, Nonoxinol, Efficiency, Bibliographic review, Human

    Logo du centre Notice produite par :
    Inist-CNRS - Institut de l'Information Scientifique et Technique

    Cote : 98-0221082

    Code Inist : 002B30A01A2. Création : 11/09/1998.