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  1. N-benzoyl, L-glutamic acid as a suitable internal standard for the analysis of trans, trans-muconic acid in human urine by liquid chromatography.

    Article - En anglais

    Urinary trans, trans-muconic acid is a sensitive biomarker for low level benzene exposure.

    The method described by Ducos et al. (Int Arch Occup Environ Health 1990 ; 62 : 529-34) is commonly used for its determination.

    In this study, we demonstrate that N-benzoyl, L-glutamic acid added to urine samples is a suitable internal standard to control trans, trans-muconic acid recovery after solid phase extraction of urine and to compensate for variations which might occur during high-performance liquid chromatography analysis.

    Mots-clés Pascal : Benzène, Analyse quantitative, Urine, Homme, Méthode étude, Extraction SPE, Chromatographie HPLC, Exposition professionnelle, Médecine travail, Analyse routine, Composé organique, Liquide biologique, Muconique acide

    Mots-clés Pascal anglais : Benzene, Quantitative analysis, Urine, Human, Investigation method, Solid phase extraction, HPLC chromatography, Occupational exposure, Occupational medicine, Routine analysis, Organic compounds, Biological fluid

    Logo du centre Notice produite par :
    Inist-CNRS - Institut de l'Information Scientifique et Technique

    Cote : 98-0220496

    Code Inist : 002B03L06. Création : 11/09/1998.