Background The Food and Drug Administration (FDA) has recommended that cereal-grain products be fortified with folic acid to prevent congenital neural-tube defects.
Since folic acid supplementation reduces levels of plasma homocyst (e) ine, or plasma total homocysteine, which are frequently elevated in arterial occlusive disease, we hypothesized that folic acid fortification might reduce plasma homocyst (e) ine levels.
Methods To test this hypothesis, we assessed the effects of breakfast cereals fortified with three levels of folic acid, and also containing the recommended dietary allowances of vitamins B6 and B12, in a randomized, double-blind, placebo-controlled, crossover trial in 75 men and women with coronary artery disease.
Results Plasma folic acid increased and plasma homocyst (e) ine decreased proportionately with the folic acid content of the breakfast cereal.
Cereal providing 127 mug of folic acid daily, approximating the increased daily intake that may result from the FDA's enrichment policy, increased plasma folic acid by 30.8 percent (P=0.045) but decreased plasma homocyst (e) ine by only 3.7 percent (P=0.24).
However, cereals providing 499 and 665 mug of folic acid daily increased plasma folic acid by 64.8 percent (P<0.001) and 105.7 percent (P=0.001), respectively, and decreased plasma homocyst (e) ine by 11.0 percent (P<0.001) and 14.0 percent (P=0.001), respectively. (...)
Mots-clés Pascal : Cardiopathie coronaire, Occlusion, Artère, Effet biologique, Régime alimentaire enrichi, Acide folique, Céréale pour petit déjeuner, Taux concentration, Homocystéine, Prévention, Résultat, Homme, Appareil circulatoire pathologie, Nutrition
Mots-clés Pascal anglais : Coronary heart disease, Occlusion, Artery, Biological effect, Supplemented diet, Folic acid, Breakfast cereals, Concentration factor, Prevention, Result, Human, Cardiovascular disease, Nutrition
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 98-0218776
Code Inist : 002B26E. Création : 11/09/1998.