Recent studies have pointed to the relationship between iron deficiency anemia and celiac disease, although data on the prevalence of celiac disease in anemic patients have been conflicting, and there is no agreement on the best screening procedure for CD in these patients.
Our aims were to evaluate the relationship between anemia and celiac disease (CD) from two different points of view-the hematology clinic and the pediatric gastroenterology department-and to evaluate the utility of anti-endomysial antibody determination in screening anemic patients for CD using human umbilical cord as substrate.
We studied 130 patients with CD (58 males, 72 females ; median age 18 months) diagnosed at a department of Pediatric Gastroenterology, and 85 patients with iron deficiency anemia (38 males, 47 females ; median age 48 years) observed at a hematology outpatient clinic.
From the 85 adult patients with iron deficiency anemia, we selected a subgroup of 25 subjects with no improvement in Hb after two months of iron therapy (80 mg/day orally).
Routine hematochemical tests were performed in all 215 patients.
All pediatric and adult subjects underwent immunological screening for celiac disease (AGA and EmA assay) ; intestinal biopsy was also performed on patients testing positive.
In the adult anemic patients a serum sample was stored at - 20°C on first observation, and after 6-18 months EmA on human umbilical cord were assayed. (...)
Mots-clés Pascal : Anémie ferriprive, Relation incertitude, Coeliaque maladie, Intérêt, Dépistage, Croisement réciproque, Mesure, Anticorps, Spécificité, Gliadine, Fer, Résultat, Homme, Hémopathie, Sidéropénie, Appareil digestif pathologie, Intestin pathologie, Malabsorption intestinale, Immunopathologie, Endomysium
Mots-clés Pascal anglais : Iron deficiency anemia, Uncertainty relation, Coeliac disease, Interest, Medical screening, Reciprocal cross, Measurement, Antibody, Specificity, Gliadin, Iron, Result, Human, Hemopathy, Sideropenia, Digestive diseases, Intestinal disease, Intestinal malabsorption, Immunopathology, Endomysium
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 98-0216397
Code Inist : 002B19A01. Création : 11/09/1998.