Chemical Sensitivity Syndromes refers to aggregations of symptoms marked by largely subjective neurobehavioral complaints and hypothesized links to immune system dysfunction.
The entities reviewed here consist of the Multiple Chemical Sensitivity Syndrome, the Sick Building Syndrome, the Chronic Fatigue Syndrome, and the Gulf War Syndrome.
Except for the Chronic Fatigue Syndrome, toxic chemical exposures are accorded a significant role in their etiology.
The connections are ambiguous because of the variety of chemical agents cited and, for the most part, the relatively low levels at which exposures occur.
Conventional clinical signs are also typically lacking.
Explanatory mechanisms include psychiatric diagnoses such as somatization, behavioral mechanisms such as conditioning and generalization, neuropharmacological mechanisms such as sensitization, and psychoneuroimmunological mechanisms such as those involving the hypothalamic-pituitary-adrenal axis.
Laboratory animal experimentation and controlled clinical trials, especially with inhaled material, provide the means for exploring the proffered explanations.
Mots-clés Pascal : Bâtiment malsain syndrome, Fatigue chronique syndrome, Etiologie, Immunopathologie, Système immunitaire, Sensibilisation, Homme, Animal, Conditionnement instrumental, Embrasement, Symptomatologie, Guerre du Golfe syndrome, Sensibilité chimique multiple
Mots-clés Pascal anglais : Sick building syndrome, Chronic fatigue syndrome, Etiology, Immunopathology, Immune system, Sensitization, Human, Animal, Instrumental conditioning, Kindling, Symptomatology, Multiple chemical sensitivity
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 98-0212172
Code Inist : 002B30A02A. Création : 11/09/1998.