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  1. Results of intermediate measures from a population-based, randomized trial of mammographic screening prevalence and detection of breast carcinoma among Asian women the Singapore breast screening project.

    Article - En anglais


    Although increasing rates of breast carcinoma incidence have been observed in Asian countries, appropriate strategies for detecting early stage breast carcinoma in such communities have been difficult to formulate, particularly because no large population screening trial specifically involving Asian women has been reported.

    The objective of this study was to evaluate the effectiveness and quality of mammography as a screening technique for Singaporean women, who are predominantly Chinese.


    In this prospective study, 166,600 women in Singapore ages 50-64 years were randomized to either 2-view mammography without physical examination (67,656) or observation (97,294, controls) over 2 years.


    Of these women, 28,231 (41.7%) responded and were screened ; they were more likely to be married, have more formal education, be working, be Chinese, and be in a higher socioeconomic group (P<0.001 for all variables).

    To assess for response bias that could affect outcome, results were also evaluated for nonrespondents (n=39,425).

    The incidence rate of cancers among nonrespondents (1 per 1000 woman-years) was less than the 1.3 in women not invited to have screening (P=0.03, relative risk [RR], 1.3 ; 95% confidence interval [CI], 1.0-1.7).

    However, cancers arising from nonrespondents did not differ significantly in stage distribution when compared with cancers within the control group.

    For every 1000 women screened, 4.8 cancers were detected. (...)

    Mots-clés Pascal : Carcinome, Glande mammaire, Stade précoce, Mammographie, Dépistage, Chinois, Ethnie, Singapour, Asie, Homme, Tumeur maligne, Glande mammaire pathologie, Radiodiagnostic

    Mots-clés Pascal anglais : Carcinoma, Mammary gland, Early stage, Mammography, Medical screening, Chinese, Ethnic group, Singapore, Asia, Human, Malignant tumor, Mammary gland diseases, Radiodiagnosis

    Logo du centre Notice produite par :
    Inist-CNRS - Institut de l'Information Scientifique et Technique

    Cote : 98-0211792

    Code Inist : 002B20E02. Création : 11/09/1998.