Multivariate genetic analysis of the causes of temperance board registrations : In all Swedish male-female twin pairs born 1926-1949.
Background TheTemperance Boards in Sweden registered individuals for three reasons : public drunkenness, driving under the influence of alcohol and committing a crime in connection with alcohol.
We wanted to ascertain whether these three forms of alcohol-related problems result from similar or different genetic and environmental risk factors.
Method We conducted a trivariate twin analysis ofthese three causes of registration in all male-female twin pairs of known zygosity born in Sweden, 1926-1949 (n=5177 twin pairs).
Results Prevalences of registration for public drunkenness, drink-driving and alcohol-related crime were, respectively, 9.0,3.6 and 4.0%. The best-fitting model had one general genetic and one general familial environmental factor with specific genetic risk factors for drink-driving and specific familial - environmental risk factors for alcohol-related crime.
Conclusions The three causes for alcohol registration in Sweden largely reflect the same genetic and environmental risk factors.
Estimated heritabilities were similar for the three forms of registration.
However, specific genetic risk factors exist for drink-driving and specific familial environmental risk factors for alcohol-related crime.
Genetic factors are somewhat less important and familial - environmental factors more important for public drunkenness than for drink-driving and alcohol related crime.
Mots-clés Pascal : Consommation, Boisson alcoolisée, Ebriété, Conduite véhicule, Criminalité, Etude familiale, Facteur risque, Génétique, Interaction génotype environnement, Jumeau monozygote, Jumeau dizygote, Epidémiologie, Etude longitudinale, Santé mentale, Homme
Mots-clés Pascal anglais : Consumption, Alcoholic beverage, Inabriation, Vehicle driving, Criminality, Family study, Risk factor, Genetics, Genotype environment interaction, Monozygotic twin, Dizygotic twin, Epidemiology, Follow up study, Mental health, Human
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 98-0211731
Code Inist : 002B18C05B. Création : 11/09/1998.