Common mechanism of toxicity : A case study of organophosphorus pesticides.
The Food Quality Protection Act of 1996 (FQPA) requires the EPA to consider « available information concerning the cumulative effects of such residues and other substances that have a common mechanism of toxicity... in establishing, modifying, leaving in effect, or revoking a tolerance for a pesticide chemical residue. » This directive raises a number of scientific questions to be answered before the FQPA can be implemented.
Among these questions is : What constitutes a common mechanism of toxicity ?
The ILSI Risk Science Institute (RSI) convened a group of experts to examine this and other scientific questions using the organophosphorus (OP) pesticides as the case study.
OP pesticides share some characteristics attributed to compounds that act by a common mechanism, but produce a variety of clinical signs of toxicity not identical for all OP pesticides.
The Working Group generated a testable hypothesis, anticholinesterase OP pesticides act by a common mechanism of toxicity, and generated alternative hypotheses that, if true, would cause rejection of the initial hypothesis and provide criteria for subgrouping OP compounds.
Some of the alternate hypotheses were rejected outright and the rest were not supported by adequate data.
The Working Group concluded that OP pesticides act by a common mechanism of toxicity if they inhibit acetylcholinesterase by phosphorylation and elicit any spectrum of cholinergic effects. (...)
Mots-clés Pascal : Toxicité, Pesticide, Organophosphoré, Analyse risque, Méthode étude, Mécanisme action, Système nerveux pathologie, Homme, Acetylcholinesterase, Carboxylic ester hydrolases, Esterases, Hydrolases, Enzyme, Organisme réglementation, Etats Unis, Amérique du Nord, Amérique
Mots-clés Pascal anglais : Toxicity, Pesticides, Organophosphorus compounds, Risk analysis, Investigation method, Mechanism of action, Nervous system diseases, Human, Acetylcholinesterase, Carboxylic ester hydrolases, Esterases, Hydrolases, Enzyme, Regulatory institution, United States, North America, America
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 98-0210399
Code Inist : 002B03G. Création : 11/09/1998.