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  1. W64R mutation in bêta-3-adrenergic receptor gene and weight in a large population sample.

    Article - En anglais

    We have investigated the W64R (Trp64Arg) mutation in the bêta-3-adrenergic receptor in 2270 healthy British males aged 50-61 y. The frequency of the rare R allele was 0.07 (95% confidence interval (CI) 0.06-0.08).

    The men showed an absence of association between W64R genotype and weight or height, both in the whole sample and in each quintile of the body mass index (BMI), and there was no association with tendency to gain weight.

    The W64R heterozygous state appears not to be a major contributing factor to obesity in the general population.

    Mots-clés Pascal : Récepteur bêta-adrénergique, Mutation, Gène, Etude comparative, Poids corporel, Taille corporelle, Indice masse corporelle, Réaction chaîne polymérase, Génotype, Epidémiologie, Royaume Uni, Europe, Adulte, Homme, Mâle, Biologie moléculaire

    Mots-clés Pascal anglais : bêta-Adrenergic receptor, Mutation, Gene, Comparative study, Body weight, Body size, Body mass index, Polymerase chain reaction, Genotype, Epidemiology, United Kingdom, Europe, Adult, Human, Male, Molecular biology

    Logo du centre Notice produite par :
    Inist-CNRS - Institut de l'Information Scientifique et Technique

    Cote : 98-0206945

    Code Inist : 002B30A01A2. Création : 11/09/1998.