Intractable headaches, the so-called'lupus headaches'have been long thought of as a common and characteristic manifestation of systemic lupus erythematosus (SLE).
Seventy-eight patients with SLE, including 10 patients with definite central nervous system (CNS) involvement, and 89 healthy individuals matched for age, sex and socioeconomic status, were studied by a specific questionnaire addressing the characteristics and type of headache.
Clinical features of SLE, neurological manifestations and treatment, disease severity and autoantibody profiles were correlated to the presence of headache.
One year prevalence of headache was similar between patients (32%) and otherwise healthy individuals (30%). No significant differences regarding frequency, family history of headache and need for analgesic medication were observed.
Headache refractory to analgesic treatment, but responsive to corticosteroid regimen, was recorded in only one patient.
Clinical and serological features of SLE, including Raynaud's phenomenon and the presence of andicardiolipin antibodies, were not significantly different between headache sufferers and non-sufferers.
In the majority of patients reporting headache, anxiety and/or depression co-existed.
Episodic tension headache was the most frequent type, while migraine was traced in a quarter of headache sufferers.
Neither the presence nor the clinical type of headache was related to, or predictive of, the development of seizures or psychosis. (...)
Mots-clés Pascal : Lupus érythémateux, Disséminé, Complication, Céphalée, Symptomatologie, Homme, Epidémiologie, Prévalence, Analyse corrélation, Traitement, Anticorps, Autoanticorps, Evolutivité, Indice gravité, Douleur, Peau pathologie, Tissu conjonctif pathologie, Maladie système, Maladie autoimmune, Immunopathologie, Système nerveux pathologie, Trouble neurologique, Anticardiolipine syndrome
Mots-clés Pascal anglais : Lupus erythematosus, Disseminated, Complication, Headache, Symptomatology, Human, Epidemiology, Prevalence, Correlation analysis, Treatment, Antibody, Autoantibody, Evolutivity, Severity score, Pain, Skin disease, Connective tissue disease, Systemic disease, Autoimmune disease, Immunopathology, Nervous system diseases, Neurological disorder, Anticardiolipin syndrome
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 98-0206870
Code Inist : 002B07. Création : 11/09/1998.