The authors examined the hypothesized association between the body burden of polychlorinated biphenyls (PCB) in women and the risk of low birth weight for their infants.
In Sweden, a main exposure route for PCBs and other persistent organochlorine compounds is through the consumption of fatty fish from the Baltic Sea (on the Swedish east coast).
A previous comparison between a cohort of consumers of large quantities of fish from the Swedish east coast and a reference population, together with a following analysis based on questionnaire data from a case-control study within the east coast cohort, supported the hypothesized association.
In 1995, blood samples were collected from the wives and ex-wives of fishermen from the Swedish east coast (n=192) who had given birth during the period 1973-1991.
Cases (n=57), i.e., infants with low birth weight (1,500-2,750 g), were matched with controls (n=135 ; birth weight, 3,250-4,500 g) on gender, parity, and calendar year of birth.
The concentration of 2,2'4,4'5,5'-hexachlorobiphenyl (CB-153) in plasma was analyzed ; it has been suggested that CB-153 is a relevant biomarker of exposure to PCBs.
The concentration of CB-153 in the plasma of mothers during the year of childbirth was « estimated » using some alternative plausible kinetic models. (...)
Mots-clés Pascal : Intoxication, Organochloré, Alimentation, Régime alimentaire enrichi, Pisces, Vertebrata, Effet biologique, Poids naissance faible, Incidence, Epidémiologie, Homme, Toxicomanie, Nutrition, Gestation pathologie, Prématurité, Nouveau né pathologie
Mots-clés Pascal anglais : Poisoning, Organochlorine compounds, Feeding, Supplemented diet, Pisces, Vertebrata, Biological effect, Low birth weight, Incidence, Epidemiology, Human, Drug addiction, Nutrition, Pregnancy disorders, Prematurity, Newborn diseases
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 98-0206715
Code Inist : 002B03L06. Création : 11/09/1998.