To analyze the effect of HLA-DR genes on susceptibility to and severity of ankylosing spondylitis (AS).
Three hundred sixty-three white British AS patients were studied ; 149 were carefully assessed for a range of clinical manifestations, and disease severity was assessed using a structured questionnaire.
Limited HLA class I typing and complete HLA-DR typing were performed using DNA-based methods.
HLA data from 13,634 healthy white British bone marrow donors were used for comparison.
A significant association between DR1 and AS was found, independent of HLA-B27 (overall odds ratio [OR] 1.4,95% confidence interval [95% CI] 1.1-1.8,0.02 ; relative risk [RR] 2.7,95% CI 1.5-4.8, P=6 x 10-4 among homozygotes ; RR 2.1,95% CI 1.5-2.8, P=5 x 10-6 among heterozygotes).
A large but weakly significant association between DR8 and AS was noted, particularly among DR8 homozygotes (RR 6.8,95% CI 1.6-29.2, P=0.01 among homozygotes ; RR 1.6,95% CI 1.0-2.7, P=0.07 among heterozygotes).
A negative association with DR12 (OR 0.22,95% Cl 0.09-0.5, P=0.001) was noted.
HLA-DR7 was associated with younger age at onset of disease (mean age at onset 18 years for DR7-positive patients and 23 years for DR7-negative patients ; Z score 3.21, P=0.001).
No other HLA class I or class II associations with disease severity or with different clinical manifestations of AS were found.
Mots-clés Pascal : Spondylarthrite ankylosante, Pathogénie, Indice gravité, Déterminisme génétique, Exploration, DNA, Système HLA, Locus HLA-D, Homme, Epidémiologie, Symptomatologie, Chronique, Système ostéoarticulaire pathologie, Rhumatisme inflammatoire, Spondylarthropathie
Mots-clés Pascal anglais : Ankylosing spondylitis, Pathogenesis, Severity score, Genetic determinism, Exploration, DNA, HLA-System, HLA-D-Locus, Human, Epidemiology, Symptomatology, Chronic, Diseases of the osteoarticular system, Inflammatory joint disease, Spondylarthropathy
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 98-0206524
Code Inist : 002B15D. Création : 11/09/1998.