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  1. alpha-Fluoro-bêta-alanine in urine of workers occupationally exposed to 5-fluorouracil in a 5-fluorouracil-producing factory.

    Article - En anglais

    Because of possible harmful health effects increased attention is being paid to the occupational exposure to cytostatic drugs of workers in hospitals and industry.

    In this study a biomarker for exposure to 5-fluorouracil (5FU) based on GC-MSMS was applied to study the occupational exposure of four workers in a pharmaceutical factory producing 5FU.

    The four workers all excreted alpha-fluoro-bêta-alanine (FBAL), a metabolite of 5FU, via the urine (range excretion rates : 0-88.9 mug per 8h).

    This is in accordance with the presence of 5FU and/or its precursor ethoxyfluorouracil (EFU) in stationary and personal air samples as well as in wipe samples taken from the floor at the workplace.

    Mots-clés Pascal : Industrie pharmaceutique, Anticancéreux, Exposition professionnelle, Médecine travail, Homme, Surveillance biologique, Urine, Liquide biologique, Marqueur biologique, Toxicité

    Mots-clés Pascal anglais : Pharmaceutical industry, Antineoplastic agent, Occupational exposure, Occupational medicine, Human, Biological monitoring, Urine, Biological fluid, Biological marker, Toxicity

    Logo du centre Notice produite par :
    Inist-CNRS - Institut de l'Information Scientifique et Technique

    Cote : 98-0206461

    Code Inist : 002B02U10. Création : 11/09/1998.