The objective of this study was to determine whether pregnancy is associated with an acceleration of human immunodeficiency virus (HIV) disease progression in women who have a pregnancy while HIV infected.
A retrospective review of all women aged 15-35 years who attended an HIV outpatient program from January 1989 through August 1995, was undertaken.
The 192 women who had a term pregnancy after testing positive for HIV were compared with 164 women who were not pregnant during the same period.
The main outcome measures were death, the occurrence of a first acquired immunodeficiency syndrome (AIDS) - defining condition, or a condition indicative of symptomatic HIV.
Disease progression was assessed using the Kaplan-Meier method and multivariate proportional hazards models.
Compared with nonpregnant women, women with a term pregnancy were significantly more likely to be African-American (88% vs. 78%, p<0.05), younger than 22 years of age (51% vs. 11%, p<0.001), and to have entered the clinic with a higher median CD4 count (519 vs. 433 cells/mul, p<0.001).
After adjusting for entry CD4 count and other factors, pregnancy was not associated with progression to any of the study outcomes.
Thus, in women attending a publicly funded clinic, pregnancy does not appear to accelerate the progression of HIV disease.
Mots-clés Pascal : Gestation, Complication, SIDA, Virose, Infection, Virus immunodéficience humaine, Lentivirus, Retroviridae, Virus, Relation incertitude, Augmentation, Incidence, Facteur risque, Epidémiologie, Homme, Femelle, Immunopathologie, Immunodéficit
Mots-clés Pascal anglais : Pregnancy, Complication, AIDS, Viral disease, Infection, Human immunodeficiency virus, Lentivirus, Retroviridae, Virus, Uncertainty relation, Increase, Incidence, Risk factor, Epidemiology, Human, Female, Immunopathology, Immune deficiency
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 98-0206265
Code Inist : 002B05C02D. Création : 11/09/1998.