JOURNAL OF OCCUPATIONAL AND ENVIRONMENTAL MEDICINE, vol. 40, n° 3, 1998, pages 217-222, 24 réf., ISSN 1076-2752, USA
KOIZUMI (A.), NOMIYAMA (T.), TSUKADA (M.), WADA (Y.), OMAE (K.), TANAKA (S.) *, MIYAUCHI (H.), IMAMIYA (S.), SAKURAI (H.)
Department of Hygiene. Akita University School of Medicine. Akita. JPN, Department of Preventive Medicine and Public Health. School of Medicine. Keio University. Tokyo. JPN, The Association of Industry Health. Tama. JPN
Hydrazine (N2H4), which has been categorized as a weak carcinogen, is a chemical with the one of the largest production rates in Japan.
We have investigated the effects of acetylation phenotypes on the metabolism of hydrazine.
Genotypes of N-acetyl transferases, NAT2*, were determined using polymerase chain reaction for 297 male workers.
Biological and exposure monitoring were also conducted.
The rapid and intermediate acetylators accounted for 45% each, and the slow acetylators accounted for 10%. Biological half-lives were significantly different among the three acetylation phenotypes (analysis of variance, P<0.05) : 3.94 ± 1.70 hours for slow acetylators, 2.25 ± 0.37 hours for intermediate acetylators, and 1.86 ± 0.67 hours for rapid acetylators.
Among Japanese, rapid and intermediate acetylators are the major phenotypes, which is in sharp contrast with those among Caucasians.
We conclude that biological monitoring should take genetic factors, which may vary dramatically among different populations, into account.
Mots-clés BDSP : Carcinogène, Exposition professionnelle, Médecine travail, Homme, Japon, Asie, Génétique, Enzyme
Mots-clés Pascal : Hydrazine, Toxicité, Carcinogène, Exposition professionnelle, Médecine travail, Homme, Japon, Asie, Métabolisme, Comparaison interindividuelle, Polymorphisme, Génétique, Surveillance biologique, Arylamine N-acetyltransferase, Acyltransferases, Transferases, Enzyme
Mots-clés Pascal anglais : Hydrazine, Toxicity, Carcinogen, Occupational exposure, Occupational medicine, Human, Japan, Asia, Metabolism, Interindividual comparison, Polymorphism, Genetics, Biological monitoring, Arylamine N-acetyltransferase, Acyltransferases, Transferases, Enzyme
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Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 98-0203012
Code Inist : 002B03L06. Création : 11/09/1998.