logo BDSP

Base documentaire


Votre avis nous intéresse

Le réseau BDSP met en oeuvre un projet d'innovation et d'amélioration de ses services, dans le souci constant de proposer des contenus de qualité adaptés aux besoins des utilisateurs.

Identifier de nouvelles sources de financements est la condition nécessaire pour assurer la poursuite et la pérennité de cet outil unique qu'est la BDSP, tout en le faisant évoluer.

Pour définir un nouveau modèle économique, nous avons besoin de votre avis : merci de répondre à notre enquête (temps estimé : 5 minutes).

Participer maintenant
Participer plus tard J'ai déjà participé

  1. Objectives, design and recruitment of a familial and longitudinal cohort for studying gene-environment interactions in the field of cardiovascular risk : The Stanislas Cohort.

    Article - En anglais

    The main objective of the Stanislas cohort is to study the role and the contribution of genetic and environmental factors to cardiovascular status.

    We plan : a) to describe the degree of association of a large number of cardiovascular risk indicators with cardiovascular endpoints, b) to evaluate the contribution of genetic and that of environmental factors to this association, c) to follow the evolution of these risk indicators during a period of at least ten years, d) to search for the determinants influencing this evolution.

    The principal variables studied are : a) blood pressure, cardiac mass, and wall thickness of carotid and femoral arteries, b) obesity and fat mass, c) indicators of lipid metabolism, d) genetic polymorphisms of several cardiovascular risk candidate genes, e) food, tobacco and alcohol consumption, f) consumption of drugs and anti-oxidant vitamins.

    Between September 1993 and August 1995,1006 families consisting of the two biological parents with at least two children were recruited totalling 4295 individuals.

    This cohort will be followed up until 2004.

    There will be two health examinations five and ten years after the initial examination.

    A bank of blood samples (serum and plasma) in liquid nitrogen and DNA (-80 °C) has been established.

    Mots-clés Pascal : Marqueur biologique, Facteur risque, Interaction génotype environnement, Homme, Sérum, Plasma sanguin, Etude familiale, Etude longitudinale, Surveillance population, Epidémiologie, Appareil circulatoire pathologie, Sang, Liquide biologique, Lorraine, France, Europe

    Mots-clés Pascal anglais : Biological marker, Risk factor, Genotype environment interaction, Human, Serum, Blood plasma, Family study, Follow up study, Population survey, Epidemiology, Cardiovascular disease, Blood, Biological fluid, Lorraine, France, Europe

    Logo du centre Notice produite par :
    Inist-CNRS - Institut de l'Information Scientifique et Technique

    Cote : 98-0202777

    Code Inist : 002B12B06. Création : 11/09/1998.