Ionized calcium (Ca2+), phosphate, albumin, total calcium, and pH measurements taken from participants in a large population-based epidemiological study were examined to determine the change in physiological variation with age for persons over 43 years old.
Only Ca2+showed a statistically significant increase in SD with age (p<0.0001).
The Ca 2+coefficients of variation (CV) increased from 2.92% in the youngest age group (43-54 years) to 3.69% in the oldest age group (75-86 years of age).
In females, the increase in Ca2+variability was nearly complete by age 55.
Males also showed a significant (p=0.006) increase in SD between the 43-54 age group and the 55-64 age group, however, Ca2+variability did not plateau after age 55 in men as it did in women.
In the 43-54 (p=0.04) and 55-64 (p=0.03) age group men showed significantly better physiological control of Ca+than women.
Phosphate showed a slight decrease in CV with age.
These data suggest that Ca2+homeostasis is disrupted in the same age groups that are most vulnerable to osteoporosis.
Mots-clés Pascal : Ostéoporose, Calcium, Ion, Sexe, Age, Epidémiologie, Mesure, Facteur risque, Homme, Etats Unis, Amérique du Nord, Amérique, Système ostéoarticulaire pathologie, Ostéopathie
Mots-clés Pascal anglais : Osteoporosis, Calcium, Ions, Sex, Age, Epidemiology, Measurement, Risk factor, Human, United States, North America, America, Diseases of the osteoarticular system, Bone disease
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 98-0202657
Code Inist : 002B15A. Création : 11/09/1998.