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  1. Epidemiological evidence for the disruption of ionized calcium homeostasis in the elderly.

    Article - En anglais

    Ionized calcium (Ca2+), phosphate, albumin, total calcium, and pH measurements taken from participants in a large population-based epidemiological study were examined to determine the change in physiological variation with age for persons over 43 years old.

    Only Ca2+showed a statistically significant increase in SD with age (p<0.0001).

    The Ca 2+coefficients of variation (CV) increased from 2.92% in the youngest age group (43-54 years) to 3.69% in the oldest age group (75-86 years of age).

    In females, the increase in Ca2+variability was nearly complete by age 55.

    Males also showed a significant (p=0.006) increase in SD between the 43-54 age group and the 55-64 age group, however, Ca2+variability did not plateau after age 55 in men as it did in women.

    In the 43-54 (p=0.04) and 55-64 (p=0.03) age group men showed significantly better physiological control of Ca+than women.

    Phosphate showed a slight decrease in CV with age.

    These data suggest that Ca2+homeostasis is disrupted in the same age groups that are most vulnerable to osteoporosis.

    Mots-clés Pascal : Ostéoporose, Calcium, Ion, Sexe, Age, Epidémiologie, Mesure, Facteur risque, Homme, Etats Unis, Amérique du Nord, Amérique, Système ostéoarticulaire pathologie, Ostéopathie

    Mots-clés Pascal anglais : Osteoporosis, Calcium, Ions, Sex, Age, Epidemiology, Measurement, Risk factor, Human, United States, North America, America, Diseases of the osteoarticular system, Bone disease

    Logo du centre Notice produite par :
    Inist-CNRS - Institut de l'Information Scientifique et Technique

    Cote : 98-0202657

    Code Inist : 002B15A. Création : 11/09/1998.