Building-associated pulmonary disease from exposure to Stachybotrys chartarum and Aspergillus versicolor.
The authors present an outbreak of disease associated with exposure to Stachybotrys chartarum and Aspergillus species.
A courthouse and two associated office buildings had generated discomfort among employees for two years since initial occupancy.
Multiple interventions had been unsuccessful.
An initial evaluation of 14 individuals identified three with potential asthma and three with symptoms consistent with interstitial lung disease.
A clinical screening protocol to identify individuals who should be removed from work identified three likely and seven possible cases of building-related asthma.
Detailed environmental and engineering assessments of the building identified major problems in mechanical system design, building construction, and operational strategies leading to excess moisture and elevated relative humidities.
Moisture-damaged interior surfaces in both buildings were contaminated with S. chartarum, A. versicolor, and Penicillium species.
Aspergillus species, especially A. versicolor, at concentrations of 101 to 104/m3 dominated the indoor air under normal operating conditions.
Bulk samples also revealed large quantities of Stachybotris.
A questionnaire survey of the three case and two control buildings documaneted between three-and 15-fold increases in symptoms.
A nested case-control study suggested emphysematous-like disease in individuals meeting questionnaire definitions for cases. (...)
Mots-clés Pascal : Bâtiment malsain syndrome, Pollution intérieur, Lieu travail, Stachybotrys chartarum, Fungi Imperfecti, Fungi, Thallophyta, Aspergillus versicolor, Epidémie, Homme, Teneur air ambiant, Symptomatologie, Epidémiologie, Moisissure, Humidité, Poumon, Appareil respiratoire pathologie, Toxicité
Mots-clés Pascal anglais : Sick building syndrome, Indoor pollution, Work place, Stachybotrys chartarum, Fungi Imperfecti, Fungi, Thallophyta, Aspergillus versicolor, Epidemic, Human, Ambient air concentration, Symptomatology, Epidemiology, Mould, Humidity, Lung, Respiratory disease, Toxicity
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 98-0202059
Code Inist : 002B05D02C. Création : 11/09/1998.