Objectives The purpose of the present report was to assess whether occupational magnetic field exposure is a risk factor for dementia, in particular for Alzheimer's disease.
Methods Case-control analyses were applied to 77 dementia cases. 55 of whom had Alzheimer's disease, ascertained from the population-based Swedish twin register.
Two reference groups were derived, with 228 and 238 persons, respectively.
Occupations were linked to a job-exposure matrix based on magnetic field measurements.
Primary occupation, last occupation before reference date, and the occupation with the highest magnetic field exposure during the subject's lifetime were evaluated.
Results For primary occupations all relative risk estimates were close to unity.
For last occupation, at the exposure level = 0.2 pT, a relative risk was found for dementia estimated at 3.3 [95% confidence interval (95% CI) 1.3-8.6] and 3.8 (95% Cl 1.4-10.2) for reference groups 1 and 2, respectively.
The relative risk for Alzheimer's disease was estimated at 2.4 (95% Cl 0.8-4.9) and 2.7 (95% Cl 0.9-7.8), respectively.
For the occupation with the highest magnetic field exposure, the relative risk estimates were close to unity for reference group I and slightly elevated for reference group 2. The relative risk estimates were greater for the subjects who were younger at onset (<=75 years). (...)
Mots-clés Pascal : Champ électromagnétique, Exposition professionnelle, Homme, Démence Alzheimer, Epidémiologie, Champ magnétique, Médecine travail, Suède, Europe, Effet biologique, Système nerveux pathologie, Système nerveux central pathologie, Encéphale pathologie, Maladie dégénérative
Mots-clés Pascal anglais : Electromagnetic field, Occupational exposure, Human, Alzheimer disease, Epidemiology, Magnetic field, Occupational medicine, Sweden, Europe, Biological effect, Nervous system diseases, Central nervous system disease, Cerebral disorder, Degenerative disease
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 98-0201780
Code Inist : 002B17G. Création : 11/09/1998.