Objectives This study tested a simple model of the relationship between the lead concentration in bone (bone-Pb), exposure time, and lead in plasma (P-Pb) and whole blood (B-Pb) to make it possible to use bone-Pb as a retrospective exposure index.
Methods Seventy-seven active lead workers and 24 referents were studied.
The bone-Pb in tibia (T-Pb) and calcaneus (C-Pb) was measured by in vivo X-ray fluorescence.
P-Pb was calculated from B-Pb by use of the nonlinear relationship between these variables.
Cumulative B-Pb (cumB-Pb) and P-Pb (cumP-Pb) were calculated to the time of the bone-Pb measurements.
In addition, cumP-Pb was adjusted by applying varying rate constants for the transfer of lead from bone to plasma.
Results There were close linear associations between the lead concentrations in tibia (proportion of variance explained.
R2=0.78) and calcaneus (R2=0.80), on one hand and the cumB-Pb on the other.
The best fit of bone-Pb to the adjusted cumP-Pb (0.79 for T-Pb ; 0.82 for C-Pb) was obtained for the terminal phase half-times of 13 and 12 years, respectively.
Conclusions The combined data on bone-Pb and exposure time make it possible to estimate previous mean P-Pb and B-Pb.
Such estimates will be valuable in studies of toxic effects on long-term exposed lead workers when data on the intensity of previous exposure are lacking. (...)
Mots-clés Pascal : Plomb, Métal lourd, Exposition professionnelle, Taux, Sang, Os, Tibia, Calcanéum, Pharmacocinétique, Toxicocinétique, Temps exposition, Rétrospective, Surveillance biologique, Homme, Médecine travail, Modèle mathématique, Histoire professionnelle
Mots-clés Pascal anglais : Lead, Heavy metal, Occupational exposure, Rate, Blood, Bone, Tibia, Calcaneum, Pharmacokinetics, Toxicokinetics, Exposure time, Retrospective, Biological monitoring, Human, Occupational medicine, Mathematical model
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 98-0201779
Code Inist : 002B03L05. Création : 11/09/1998.