Effects of long-term organophosphate exposures on neurological symptoms, vibration sense and tremor among South African farm workers.
Objectives This study assessed the relationship between long-term exposure to organophosphate insecticides and neurological symptoms, vibration sense, and motor tremor after control for the effect of past poisoning and acute exposure.
Methods This cross-sectional study included 164 pesticide applicators and 83 nonspraying reference workers on deciduous fruit farms.
The workers were tested on the Vibratron II, on tests of dynamic and static tremor, and for a set of neurological and « dummy » symptoms.
Exposure was derived with the use of a job-exposure matrix for pesticides in agriculture.
Results Compared with nonapplicators, current applicators reported significantly more dizziness, sleepiness, and headache and had a higher overall neurological symptom score.
This association remained statistically significant after multiple logistic regression analyses controlling for a range of confounders and effect modifiers [odds ratio (OR) 2.25. for current applicators having high neurological score, 95% confidence interval (95% Cl) 1.15-4.39]. The avenge lifetime intensity oforganophosphate exposure was nonsignificantly associated with both neurological (OR 1.98,95% Cl 0.49-7.94) and « dummy » symptoms (OR 2.37,95% Cl 0.54-10.35).
Previous pesticide poisoning was significantly associated with the neurological scores (OR 4.08,95% Cl 1.48-1 1.22) but not with the « dummy » symptoms. (...)
Mots-clés Pascal : Organophosphoré, Insecticide, Pesticide, Tremblement, Homme, Système nerveux central, Perception sensorielle, Vibration, Toxicité, Long terme, Exposition professionnelle, Agriculture, Pulvérisation, République Sud Africaine, Afrique, Système nerveux pathologie, Trouble neurologique, Mouvement involontaire, Médecine travail, Epidémiologie
Mots-clés Pascal anglais : Organophosphorus compounds, Insecticide, Pesticides, Tremor, Human, Central nervous system, Sensorial perception, Vibration, Toxicity, Long term, Occupational exposure, Agriculture, Spraying, South Africa, Africa, Nervous system diseases, Neurological disorder, Involuntary movement, Occupational medicine, Epidemiology
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 98-0201777
Code Inist : 002B03G. Création : 11/09/1998.