We investigated 21 pairs of twins for zygosity and idiopathic scoliosis.
DNA fingerprinting confirmed that 13 pairs were monozygotic and eight were dizygotic.
There was concordance for idiopathic scoliosis in 92.3% of monozygotic and 62.5% of dizygotic twins.
Of the 12 pairs of monozygotic twins concordant for idiopathic scoliosis, six showed discordant curve patterns but eight had differences in Cobb angle of less than 10°. Seven of the ten pairs of monozygotic twins had similar back shapes.
Our findings suggest that there is a genetic factor in the aetiology of idiopathic scoliosis ; they also indicate that there is a genetic factor in both the severity of the curve and the general shape of the back.
Mots-clés Pascal : Scoliose, Idiopathique, Enfant, Homme, Jumeau, Déterminisme génétique, Adolescent, Epidémiologie, Incidence, Type, Méthode fingerprint, Exploration, DNA, Radiographie, Rachis, Système ostéoarticulaire pathologie, Rachis pathologie, Déformation, Génétique, Radiodiagnostic
Mots-clés Pascal anglais : Scoliosis, Idiopathic, Child, Human, Twin, Genetic determinism, Adolescent, Epidemiology, Incidence, Type, Fingerprint method, Exploration, DNA, Radiography, Spine, Diseases of the osteoarticular system, Spine disease, Deformation, Genetics, Radiodiagnosis
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 98-0194348
Code Inist : 002B15F. Création : 11/09/1998.