Idiopathic scoliosis in twins studied by DNA fingerprinting : The incidence and type of scoliosis.
We investigated 21 pairs of twins for zygosity and idiopathic scoliosis.
DNA fingerprinting confirmed that 13 pairs were monozygotic and eight were dizygotic.
There was concordance for idiopathic scoliosis in 92.3% of monozygotic and 62.5% of dizygotic twins.
Of the 12 pairs of monozygotic twins concordant for idiopathic scoliosis, six showed discordant curve patterns but eight had differences in Cobb angle of less than 10°. Seven of the ten pairs of monozygotic twins had similar back shapes.
Our findings suggest that there is a genetic factor in the aetiology of idiopathic scoliosis ; they also indicate that there is a genetic factor in both the severity of the curve and the general shape of the back.
Mots-clés Pascal : Scoliose, Idiopathique, Enfant, Homme, Jumeau, Déterminisme génétique, Adolescent, Epidémiologie, Incidence, Type, Méthode fingerprint, Exploration, DNA, Radiographie, Rachis, Système ostéoarticulaire pathologie, Rachis pathologie, Déformation, Génétique, Radiodiagnostic
Mots-clés Pascal anglais : Scoliosis, Idiopathic, Child, Human, Twin, Genetic determinism, Adolescent, Epidemiology, Incidence, Type, Fingerprint method, Exploration, DNA, Radiography, Spine, Diseases of the osteoarticular system, Spine disease, Deformation, Genetics, Radiodiagnosis
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 98-0194348
Code Inist : 002B15F. Création : 11/09/1998.