Seroprevalence of anti-Borrelia antibodies among patients with confirmed sarcoidosis in a region of Japan where Lyme borreliosis is endemic.
Sarcoidosis is a multisystemic granulomatous disease of unknown etiology, while Lyme borreliosis is a multisystemic disorder caused by Borrelia burgdorferi.
The purpose of this study is to evaluate the relationship between sarcoidosis and Lyme borreliosis in a region of Japan where Lyme borreliosis is endemic..
We determined the seroprevalence of anti-Borrelia burgdorferi antibodies as well as antibodies three Japanese Borrelia strains by enzyme-linked immunosorbent assay and dotblot assay using purified Borrelia-specific proteins in 46 patients with confirmed sarcoidosis and 150 controls (50 disease controls and 100 healthy controls) in Hokkaido, the affected region..
Fifteen patients with sarcoidosis (32.6%) tested positive for Borrelia spirochete in both assays, compared with two disease controls (4.0%) and two healthy controls (2.0%). The seroprevalence of anti-Borrelia antibodies in patients with sarcoidosis was much higher in the affected region than in the region in our previous study where Lyme borreliosis is non-endemic..
In a region where Lyme borreliosis is endemic, Borrelia infection may be partially associated with sarcoidosis.
Mots-clés Pascal : Lyme maladie, Borréliose, Spirochétose, Bactériose, Infection, Borrelia burgdorferi, Spirochaetaceae, Spirochaetales, Bactérie, Anticorps, Prévalence, Sarcoïdose, Association, Japon, Asie, Homme, Maladie système
Mots-clés Pascal anglais : Lyme disease, Borrelia infection, Spirachaetosis, Bacteriosis, Infection, Borrelia burgdorferi, Spirochaetaceae, Spirochaetales, Bacteria, Antibody, Prevalence, Sarcoidosis, Association, Japan, Asia, Human, Systemic disease
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 98-0194107
Code Inist : 002B07. Création : 11/09/1998.