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  1. Helicobacter pylori infection, reflux esophagitis, and atrophic gastritis : An unexplored triangle.

    Article - En anglais

    Objective 

    H. pylori causes chronic gastritis, which may progress to peptic ulcer, gastric atrophy, or gastric cancer.

    However, little is known about the role of H. pylori infection in reflux esophagitis and the relationship between reflux esophagitis and atrophic gastritis needs to be clarified.

    We sought to identify the possible interrelationships among Helicobacter pylori infection, reflux esophagitis, and atrophic gastritis, to signal areas in which researchers should consider focusing their attention.

    Methods 

    A broad-based Medline search was performed to identify all related publications addressing H. pylori infection, atrophic gastritis, gastroesophageal reflux disease (GERD), secretion of gastric acid, and gastric motility published between 1966 and July 1997.

    Results 

    Whereas some studies have shown no significant association between H. pylori infection and reflux esophagitis, others have observed that the prevalence of H. pylori infection was lower in patients with GERD, implying a protective role.

    Eradication of H. pylori leads to occurrence of reflux esophagitis in some cases, but the mechanisms inducing posteradication reflux esophagitis are unknown.

    H. pylori infection may lead to atrophic gastritis (and hence hypochlorhydia) through both bacterial and host factors, although gastric atrophy and subsequent intestinal metaplasia are hostile to H. pylori because of hypochlorhydria. (...)

    Mots-clés Pascal : Reflux gastrooesophagien, Gastrite atrophique, Corrélation, Helicobacter pylori, Spirillaceae, Spirillales, Bactérie, Dépistage, Analyse coût efficacité, Campagne de masse, Homme, Appareil digestif pathologie, Oesophage pathologie, Bactériose, Infection, Economie santé

    Mots-clés Pascal anglais : Gastroesophageal reflux, Atrophic gastritis, Correlation, Helicobacter pylori, Spirillaceae, Spirillales, Bacteria, Medical screening, Cost efficiency analysis, Mass campaign, Human, Digestive diseases, Esophageal disease, Bacteriosis, Infection, Health economy

    Logo du centre Notice produite par :
    Inist-CNRS - Institut de l'Information Scientifique et Technique

    Cote : 98-0192836

    Code Inist : 002B05B02F. Création : 11/09/1998.