Background Amino alcohols are low molecular weight chemicals used widely in industrial processes, often as minor constituents.
They have been found to cause allergic contact dermatitis.
Marked exposure through airways is uncommon in other than occupational settings where chemicals containing amino alcohols may be heated or vaporized, liberating free amino alcohols into the ambient air.
A few cases of asthma and allergic rhinitis have been reported, but the amounts inducing the airway reactions have not been defined.
Objective To further characterize ethanolamine-induced asthma and define the concentration inducing the asthmatic reaction, a case of diethanolamine-induced occupational asthma in a patient handling diethanolamine containing cutting fluid is reported.
Methods Suspicion of work related asthma was raised by symptoms and peak expiratory flow monitorings at work and at home.
Specific bronchial provocation tests with the cutting fluid containing DEA and with DEA aerosol at two different concentration below the American Conference of Governmental Industrial Hygienists threshold limit value of DEA (2.0 mg/m3) were done.
Results DEA caused asthmatic airway obstruction at two different concentrations below the ACGIH TLV.
A slight dose-response relationship was observed.
Specific IgE-antibodies against DEA could not be found.
Conclusions DEA is able to induce occupational asthma by a sensitization mechanism, the exact pathophysiological mechanism of which is not known.
Mots-clés Pascal : Asthme, Allergie, Exposition professionnelle, Etude cas, Adulte, Homme, Aminoalcool, Fluide coupe, Finlande, Europe, Test provocation, Inhalation, Industrie métallurgique, Allergène, Diagnostic, Mâle, Appareil respiratoire pathologie, Bronchopneumopathie obstructive, Immunopathologie, Maladie professionnelle, Médecine travail, Diéthanolamine
Mots-clés Pascal anglais : Asthma, Allergy, Occupational exposure, Case study, Adult, Human, Aminoalcohol, Cutting fluid, Finland, Europe, Provocation test, Inhalation, Metallurgical industry, Allergen, Diagnosis, Male, Respiratory disease, Obstructive pulmonary disease, Immunopathology, Occupational disease, Occupational medicine
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 98-0190337
Code Inist : 002B06C02. Création : 11/09/1998.